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Temozolomide in Glioblastoma Therapy: Role of Apoptosis, Senescence and Autophagy. Comment on Strobel et al., Temozolomide and Other Alkylating Agents in Glioblastoma Therapy. Biomedicines 2019, 7, 69

Temozolomide, a DNA methylating drug, is currently being used first-line in glioblastoma therapy. Although the mode of action of this so-called S(N)1 alkylating agent is well described, including the types of induced DNA damage triggering the DNA damage response and survival and death pathways, some...

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Detalles Bibliográficos
Autor principal: Kaina, Bernd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966492/
https://www.ncbi.nlm.nih.gov/pubmed/31717973
http://dx.doi.org/10.3390/biomedicines7040090