Glucose Depletion Enhances the Stem Cell Phenotype and Gemcitabine Resistance of Cholangiocarcinoma Organoids through AKT Phosphorylation and Reactive Oxygen Species

Cancer cells are strongly dependent on the glycolytic pathway for generation of energy even under aerobic condition through a phenomenon known as the Warburg effect. Rapid proliferation of cancer cells is often accompanied by high glucose consumption and abnormal angiogenesis, which may lead to gluc...

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Detalles Bibliográficos
Autores principales: Yoshikawa, Nao, Saito, Yoshimasa, Manabe, Hiroki, Nakaoka, Toshiaki, Uchida, Ryoei, Furukawa, Ryo, Muramatsu, Toshihide, Sugiyama, Yuko, Kimura, Masaki, Saito, Hidetsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966500/
https://www.ncbi.nlm.nih.gov/pubmed/31835877
http://dx.doi.org/10.3390/cancers11121993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966500/
https://www.ncbi.nlm.nih.gov/pubmed/31835877
http://dx.doi.org/10.3390/cancers11121993

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