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Glucose Depletion Enhances the Stem Cell Phenotype and Gemcitabine Resistance of Cholangiocarcinoma Organoids through AKT Phosphorylation and Reactive Oxygen Species
Cancer cells are strongly dependent on the glycolytic pathway for generation of energy even under aerobic condition through a phenomenon known as the Warburg effect. Rapid proliferation of cancer cells is often accompanied by high glucose consumption and abnormal angiogenesis, which may lead to gluc...
Autores principales: | Yoshikawa, Nao, Saito, Yoshimasa, Manabe, Hiroki, Nakaoka, Toshiaki, Uchida, Ryoei, Furukawa, Ryo, Muramatsu, Toshihide, Sugiyama, Yuko, Kimura, Masaki, Saito, Hidetsugu |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966500/ https://www.ncbi.nlm.nih.gov/pubmed/31835877 http://dx.doi.org/10.3390/cancers11121993 |
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