Targeting Calcium Signalling in Malignant Mesothelioma †
Calcium ions (Ca(2+)) are central in cancer development and growth, serving as a major signaling system determining the cell’s fate. Therefore, the investigation of the functional roles of ion channels in cancer development may identify novel approaches for determining tumor prognosis. Malignant mes...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966506/ https://www.ncbi.nlm.nih.gov/pubmed/31766522 http://dx.doi.org/10.3390/cancers11121839 |
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author | Martinotti, Simona Patrone, Mauro Moccia, Francesco Ranzato, Elia |
author_facet | Martinotti, Simona Patrone, Mauro Moccia, Francesco Ranzato, Elia |
author_sort | Martinotti, Simona |
collection | PubMed |
description | Calcium ions (Ca(2+)) are central in cancer development and growth, serving as a major signaling system determining the cell’s fate. Therefore, the investigation of the functional roles of ion channels in cancer development may identify novel approaches for determining tumor prognosis. Malignant mesothelioma is an aggressive cancer that develops from the serosal surface of the body, strictly related to asbestos exposure. The treatment of malignant mesothelioma is complex and the survival outcomes, rather than the overall survival data are, to date, disappointedly daunting. Nevertheless, conventional chemotherapy is almost ineffective. The alteration in the expression and/or activity of Ca(2+) permeable ion channels seems to be characteristic of mesothelioma cells. In this review, we explore the involvement of the Ca(2+)toolkit in this disease. Moreover, the established sensitivity of some Ca(2+)channels to selective pharmacological modulators makes them interesting targets for mesothelioma cancer therapy. |
format | Online Article Text |
id | pubmed-6966506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69665062020-01-27 Targeting Calcium Signalling in Malignant Mesothelioma † Martinotti, Simona Patrone, Mauro Moccia, Francesco Ranzato, Elia Cancers (Basel) Review Calcium ions (Ca(2+)) are central in cancer development and growth, serving as a major signaling system determining the cell’s fate. Therefore, the investigation of the functional roles of ion channels in cancer development may identify novel approaches for determining tumor prognosis. Malignant mesothelioma is an aggressive cancer that develops from the serosal surface of the body, strictly related to asbestos exposure. The treatment of malignant mesothelioma is complex and the survival outcomes, rather than the overall survival data are, to date, disappointedly daunting. Nevertheless, conventional chemotherapy is almost ineffective. The alteration in the expression and/or activity of Ca(2+) permeable ion channels seems to be characteristic of mesothelioma cells. In this review, we explore the involvement of the Ca(2+)toolkit in this disease. Moreover, the established sensitivity of some Ca(2+)channels to selective pharmacological modulators makes them interesting targets for mesothelioma cancer therapy. MDPI 2019-11-21 /pmc/articles/PMC6966506/ /pubmed/31766522 http://dx.doi.org/10.3390/cancers11121839 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Martinotti, Simona Patrone, Mauro Moccia, Francesco Ranzato, Elia Targeting Calcium Signalling in Malignant Mesothelioma † |
title | Targeting Calcium Signalling in Malignant Mesothelioma † |
title_full | Targeting Calcium Signalling in Malignant Mesothelioma † |
title_fullStr | Targeting Calcium Signalling in Malignant Mesothelioma † |
title_full_unstemmed | Targeting Calcium Signalling in Malignant Mesothelioma † |
title_short | Targeting Calcium Signalling in Malignant Mesothelioma † |
title_sort | targeting calcium signalling in malignant mesothelioma † |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966506/ https://www.ncbi.nlm.nih.gov/pubmed/31766522 http://dx.doi.org/10.3390/cancers11121839 |
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