Targeting Calcium Signalling in Malignant Mesothelioma †

Calcium ions (Ca(2+)) are central in cancer development and growth, serving as a major signaling system determining the cell’s fate. Therefore, the investigation of the functional roles of ion channels in cancer development may identify novel approaches for determining tumor prognosis. Malignant mes...

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Autores principales: Martinotti, Simona, Patrone, Mauro, Moccia, Francesco, Ranzato, Elia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966506/
https://www.ncbi.nlm.nih.gov/pubmed/31766522
http://dx.doi.org/10.3390/cancers11121839
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author Martinotti, Simona
Patrone, Mauro
Moccia, Francesco
Ranzato, Elia
author_facet Martinotti, Simona
Patrone, Mauro
Moccia, Francesco
Ranzato, Elia
author_sort Martinotti, Simona
collection PubMed
description Calcium ions (Ca(2+)) are central in cancer development and growth, serving as a major signaling system determining the cell’s fate. Therefore, the investigation of the functional roles of ion channels in cancer development may identify novel approaches for determining tumor prognosis. Malignant mesothelioma is an aggressive cancer that develops from the serosal surface of the body, strictly related to asbestos exposure. The treatment of malignant mesothelioma is complex and the survival outcomes, rather than the overall survival data are, to date, disappointedly daunting. Nevertheless, conventional chemotherapy is almost ineffective. The alteration in the expression and/or activity of Ca(2+) permeable ion channels seems to be characteristic of mesothelioma cells. In this review, we explore the involvement of the Ca(2+)toolkit in this disease. Moreover, the established sensitivity of some Ca(2+)channels to selective pharmacological modulators makes them interesting targets for mesothelioma cancer therapy.
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spelling pubmed-69665062020-01-27 Targeting Calcium Signalling in Malignant Mesothelioma † Martinotti, Simona Patrone, Mauro Moccia, Francesco Ranzato, Elia Cancers (Basel) Review Calcium ions (Ca(2+)) are central in cancer development and growth, serving as a major signaling system determining the cell’s fate. Therefore, the investigation of the functional roles of ion channels in cancer development may identify novel approaches for determining tumor prognosis. Malignant mesothelioma is an aggressive cancer that develops from the serosal surface of the body, strictly related to asbestos exposure. The treatment of malignant mesothelioma is complex and the survival outcomes, rather than the overall survival data are, to date, disappointedly daunting. Nevertheless, conventional chemotherapy is almost ineffective. The alteration in the expression and/or activity of Ca(2+) permeable ion channels seems to be characteristic of mesothelioma cells. In this review, we explore the involvement of the Ca(2+)toolkit in this disease. Moreover, the established sensitivity of some Ca(2+)channels to selective pharmacological modulators makes them interesting targets for mesothelioma cancer therapy. MDPI 2019-11-21 /pmc/articles/PMC6966506/ /pubmed/31766522 http://dx.doi.org/10.3390/cancers11121839 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Martinotti, Simona
Patrone, Mauro
Moccia, Francesco
Ranzato, Elia
Targeting Calcium Signalling in Malignant Mesothelioma †
title Targeting Calcium Signalling in Malignant Mesothelioma †
title_full Targeting Calcium Signalling in Malignant Mesothelioma †
title_fullStr Targeting Calcium Signalling in Malignant Mesothelioma †
title_full_unstemmed Targeting Calcium Signalling in Malignant Mesothelioma †
title_short Targeting Calcium Signalling in Malignant Mesothelioma †
title_sort targeting calcium signalling in malignant mesothelioma †
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966506/
https://www.ncbi.nlm.nih.gov/pubmed/31766522
http://dx.doi.org/10.3390/cancers11121839
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