GLUL Ablation Can Confer Drug Resistance to Cancer Cells via a Malate-Aspartate Shuttle-Mediated Mechanism

Glutamate-ammonia ligase (GLUL) is important for acid-base homeostasis, ammonia detoxification, cell signaling, and proliferation. Here, we reported that GLUL ablation conferred resistance to several anticancer drugs in specific cancer cell lines while leaving other cell lines non-resistant to the s...

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Detalles Bibliográficos
Autores principales: Muthu, Magesh, Kumar, Ranjeet, Syed Khaja, Azharuddin Sajid, Gilthorpe, Jonathan D., Persson, Jenny L., Nordström, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966511/
https://www.ncbi.nlm.nih.gov/pubmed/31817360
http://dx.doi.org/10.3390/cancers11121945

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966511/
https://www.ncbi.nlm.nih.gov/pubmed/31817360
http://dx.doi.org/10.3390/cancers11121945

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