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Inhibition of PARP Sensitizes Chondrosarcoma Cell Lines to Chemo- and Radiotherapy Irrespective of the IDH1 or IDH2 Mutation Status
Chondrosarcomas are chemo- and radiotherapy resistant and frequently harbor mutations in isocitrate dehydrogenase (IDH1 or IDH2), causing increased levels of D-2-hydroxyglutarate (D-2-HG). DNA repair defects and synthetic lethality with poly(ADP-ribose) polymerase (PARP) inhibition occur in IDH muta...
Autores principales: | Venneker, Sanne, Kruisselbrink, Alwine B., Briaire-de Bruijn, Inge H., de Jong, Yvonne, van Wijnen, Andre J., Danen, Erik H.J., Bovée, Judith V.M.G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966531/ https://www.ncbi.nlm.nih.gov/pubmed/31810230 http://dx.doi.org/10.3390/cancers11121918 |
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