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The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy

The ratio of positive lymph nodes (LNs) to the total LN harvest is called the LN ratio (LNR). It is an independent prognostic factor in gastric cancer (GC). The aim of the current study was to evaluate the impact of neoadjuvant chemotherapy (NAC) on the LNR (ypLNR) in patients with advanced GC. We r...

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Autores principales: Rawicz-Pruszyński, Karol, Ciseł, Bogumiła, Mlak, Radosław, Mielko, Jerzy, Skórzewska, Magdalena, Kwietniewska, Magdalena, Pikuła, Agnieszka, Gęca, Katarzyna, Sędłak, Katarzyna, Kurylcio, Andrzej, Polkowski, Wojciech P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966566/
https://www.ncbi.nlm.nih.gov/pubmed/31805755
http://dx.doi.org/10.3390/cancers11121914
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author Rawicz-Pruszyński, Karol
Ciseł, Bogumiła
Mlak, Radosław
Mielko, Jerzy
Skórzewska, Magdalena
Kwietniewska, Magdalena
Pikuła, Agnieszka
Gęca, Katarzyna
Sędłak, Katarzyna
Kurylcio, Andrzej
Polkowski, Wojciech P.
author_facet Rawicz-Pruszyński, Karol
Ciseł, Bogumiła
Mlak, Radosław
Mielko, Jerzy
Skórzewska, Magdalena
Kwietniewska, Magdalena
Pikuła, Agnieszka
Gęca, Katarzyna
Sędłak, Katarzyna
Kurylcio, Andrzej
Polkowski, Wojciech P.
author_sort Rawicz-Pruszyński, Karol
collection PubMed
description The ratio of positive lymph nodes (LNs) to the total LN harvest is called the LN ratio (LNR). It is an independent prognostic factor in gastric cancer (GC). The aim of the current study was to evaluate the impact of neoadjuvant chemotherapy (NAC) on the LNR (ypLNR) in patients with advanced GC. We retrospectively analyzed the data of patients with advanced GC, who underwent gastrectomy with N1 and N2 (D2) lymphadenectomy between August 2011 and January 2019 in the Department of Surgical Oncology at the Medical University of Lublin. The exclusion criteria were a lack of preoperative NAC administration, suboptimal lymphadenectomy (<D2 and/or removal of less than 15 lymph nodes), and a lack of data on tumor regression grading (TRG) in the final pathological report. A total of 95 patients were eligible for the analysis. A positive correlation was found between the ypLNR and tumor diameter (p < 0.001), post treatment pathological Tumour (ypT) stage (p < 0.001), Laurén histological subtype (p = 0.0001), and the response to NAC (p < 0.0001). A multivariate analysis demonstrated that the ypLNR was an independent prognostic factor in patients with intestinal type GC (p = 0.0465) and in patients with no response to NAC (p = 0.0483). In the resection specimen, tumor diameter and depth of infiltration, Laurén histological subtype, and TRG may reflect the impact of NAC on LN status, as quantified by ypLNR in advanced GC.
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spelling pubmed-69665662020-01-27 The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy Rawicz-Pruszyński, Karol Ciseł, Bogumiła Mlak, Radosław Mielko, Jerzy Skórzewska, Magdalena Kwietniewska, Magdalena Pikuła, Agnieszka Gęca, Katarzyna Sędłak, Katarzyna Kurylcio, Andrzej Polkowski, Wojciech P. Cancers (Basel) Article The ratio of positive lymph nodes (LNs) to the total LN harvest is called the LN ratio (LNR). It is an independent prognostic factor in gastric cancer (GC). The aim of the current study was to evaluate the impact of neoadjuvant chemotherapy (NAC) on the LNR (ypLNR) in patients with advanced GC. We retrospectively analyzed the data of patients with advanced GC, who underwent gastrectomy with N1 and N2 (D2) lymphadenectomy between August 2011 and January 2019 in the Department of Surgical Oncology at the Medical University of Lublin. The exclusion criteria were a lack of preoperative NAC administration, suboptimal lymphadenectomy (<D2 and/or removal of less than 15 lymph nodes), and a lack of data on tumor regression grading (TRG) in the final pathological report. A total of 95 patients were eligible for the analysis. A positive correlation was found between the ypLNR and tumor diameter (p < 0.001), post treatment pathological Tumour (ypT) stage (p < 0.001), Laurén histological subtype (p = 0.0001), and the response to NAC (p < 0.0001). A multivariate analysis demonstrated that the ypLNR was an independent prognostic factor in patients with intestinal type GC (p = 0.0465) and in patients with no response to NAC (p = 0.0483). In the resection specimen, tumor diameter and depth of infiltration, Laurén histological subtype, and TRG may reflect the impact of NAC on LN status, as quantified by ypLNR in advanced GC. MDPI 2019-12-01 /pmc/articles/PMC6966566/ /pubmed/31805755 http://dx.doi.org/10.3390/cancers11121914 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rawicz-Pruszyński, Karol
Ciseł, Bogumiła
Mlak, Radosław
Mielko, Jerzy
Skórzewska, Magdalena
Kwietniewska, Magdalena
Pikuła, Agnieszka
Gęca, Katarzyna
Sędłak, Katarzyna
Kurylcio, Andrzej
Polkowski, Wojciech P.
The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy
title The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy
title_full The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy
title_fullStr The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy
title_full_unstemmed The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy
title_short The Role of the Lymph Node Ratio in Advanced Gastric Cancer After Neoadjuvant Chemotherapy
title_sort role of the lymph node ratio in advanced gastric cancer after neoadjuvant chemotherapy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966566/
https://www.ncbi.nlm.nih.gov/pubmed/31805755
http://dx.doi.org/10.3390/cancers11121914
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