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Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients

Prostate cancer, the second most common cancer, is still a major cause of morbidity and mortality among men worldwide. The expression of the survival and proliferation factor progranulin (GP88) has not yet been comprehensively studied in PCa tumors. The aim of this study was to characterize GP88 pro...

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Autores principales: Abdulrahman, Amer, Eckstein, Markus, Jung, Rudolf, Guzman, Juan, Weigelt, Katrin, Serrero, Ginette, Yue, Binbin, Geppert, Carol, Stöhr, Robert, Hartmann, Arndt, Wullich, Bernd, Wach, Sven, Taubert, Helge, Lieb, Verena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966571/
https://www.ncbi.nlm.nih.gov/pubmed/31888257
http://dx.doi.org/10.3390/cancers11122029
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author Abdulrahman, Amer
Eckstein, Markus
Jung, Rudolf
Guzman, Juan
Weigelt, Katrin
Serrero, Ginette
Yue, Binbin
Geppert, Carol
Stöhr, Robert
Hartmann, Arndt
Wullich, Bernd
Wach, Sven
Taubert, Helge
Lieb, Verena
author_facet Abdulrahman, Amer
Eckstein, Markus
Jung, Rudolf
Guzman, Juan
Weigelt, Katrin
Serrero, Ginette
Yue, Binbin
Geppert, Carol
Stöhr, Robert
Hartmann, Arndt
Wullich, Bernd
Wach, Sven
Taubert, Helge
Lieb, Verena
author_sort Abdulrahman, Amer
collection PubMed
description Prostate cancer, the second most common cancer, is still a major cause of morbidity and mortality among men worldwide. The expression of the survival and proliferation factor progranulin (GP88) has not yet been comprehensively studied in PCa tumors. The aim of this study was to characterize GP88 protein expression in PCa by immunohistochemistry and to correlate the findings to the clinico-pathological data and prognosis. Immunohistochemical staining for GP88 was performed by TMA with samples from 442 PCa patients using an immunoreactive score (IRS). Altogether, 233 cases (52.7%) with negative GP88 staining (IRS < 2) and 209 cases (47.3%) with positive GP88 staining (IRS ≥ 2) were analyzed. A significant positive correlation was found for the GP88 IRS with the PSA value at prostatectomy and the cytoplasmic cytokeratin 20 IRS, whereas it was negatively associated with follow-up times. The association of GP88 staining with prognosis was further studied by survival analyses (Kaplan–Meier, univariate and multivariate Cox’s regression analysis). Increased GP88 protein expression appeared as an independent prognostic factor for overall, disease-specific and relapse-free survival in all PCa patients. Interestingly, in the subgroup of younger PCa patients (≤65 years), GP88 positivity was associated with a 3.8-fold (p = 0.004), a 6.0-fold (p = 0.008) and a 3.7-fold (p = 0.003) increased risk for death, disease-specific death and occurrence of a relapse, respectively. In the PCa subgroup with negative CK20 staining, GP88 positivity was associated with a 1.8-fold (p = 0.018) and a 2.8-fold increased risk for death and disease-specific death (p = 0.028). Altogether, GP88 protein positivity appears to be an independent prognostic factor for PCa patients.
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spelling pubmed-69665712020-01-27 Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients Abdulrahman, Amer Eckstein, Markus Jung, Rudolf Guzman, Juan Weigelt, Katrin Serrero, Ginette Yue, Binbin Geppert, Carol Stöhr, Robert Hartmann, Arndt Wullich, Bernd Wach, Sven Taubert, Helge Lieb, Verena Cancers (Basel) Article Prostate cancer, the second most common cancer, is still a major cause of morbidity and mortality among men worldwide. The expression of the survival and proliferation factor progranulin (GP88) has not yet been comprehensively studied in PCa tumors. The aim of this study was to characterize GP88 protein expression in PCa by immunohistochemistry and to correlate the findings to the clinico-pathological data and prognosis. Immunohistochemical staining for GP88 was performed by TMA with samples from 442 PCa patients using an immunoreactive score (IRS). Altogether, 233 cases (52.7%) with negative GP88 staining (IRS < 2) and 209 cases (47.3%) with positive GP88 staining (IRS ≥ 2) were analyzed. A significant positive correlation was found for the GP88 IRS with the PSA value at prostatectomy and the cytoplasmic cytokeratin 20 IRS, whereas it was negatively associated with follow-up times. The association of GP88 staining with prognosis was further studied by survival analyses (Kaplan–Meier, univariate and multivariate Cox’s regression analysis). Increased GP88 protein expression appeared as an independent prognostic factor for overall, disease-specific and relapse-free survival in all PCa patients. Interestingly, in the subgroup of younger PCa patients (≤65 years), GP88 positivity was associated with a 3.8-fold (p = 0.004), a 6.0-fold (p = 0.008) and a 3.7-fold (p = 0.003) increased risk for death, disease-specific death and occurrence of a relapse, respectively. In the PCa subgroup with negative CK20 staining, GP88 positivity was associated with a 1.8-fold (p = 0.018) and a 2.8-fold increased risk for death and disease-specific death (p = 0.028). Altogether, GP88 protein positivity appears to be an independent prognostic factor for PCa patients. MDPI 2019-12-16 /pmc/articles/PMC6966571/ /pubmed/31888257 http://dx.doi.org/10.3390/cancers11122029 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Abdulrahman, Amer
Eckstein, Markus
Jung, Rudolf
Guzman, Juan
Weigelt, Katrin
Serrero, Ginette
Yue, Binbin
Geppert, Carol
Stöhr, Robert
Hartmann, Arndt
Wullich, Bernd
Wach, Sven
Taubert, Helge
Lieb, Verena
Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients
title Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients
title_full Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients
title_fullStr Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients
title_full_unstemmed Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients
title_short Expression of GP88 (Progranulin) Protein Is an Independent Prognostic Factor in Prostate Cancer Patients
title_sort expression of gp88 (progranulin) protein is an independent prognostic factor in prostate cancer patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966571/
https://www.ncbi.nlm.nih.gov/pubmed/31888257
http://dx.doi.org/10.3390/cancers11122029
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