Cargando…
Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma
Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive patterns as a prognos...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966575/ https://www.ncbi.nlm.nih.gov/pubmed/31766622 http://dx.doi.org/10.3390/cancers11121845 |
_version_ | 1783488767583059968 |
---|---|
author | Ruz-Caracuel, Ignacio Ramón-Patino, Jorge L López-Janeiro, Álvaro Yébenes, Laura Berjón, Alberto Hernández, Alicia Gallego, Alejandro Heredia-Soto, Victoria Mendiola, Marta Redondo, Andrés Peláez-García, Alberto Hardisson, David |
author_facet | Ruz-Caracuel, Ignacio Ramón-Patino, Jorge L López-Janeiro, Álvaro Yébenes, Laura Berjón, Alberto Hernández, Alicia Gallego, Alejandro Heredia-Soto, Victoria Mendiola, Marta Redondo, Andrés Peláez-García, Alberto Hardisson, David |
author_sort | Ruz-Caracuel, Ignacio |
collection | PubMed |
description | Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive patterns as a prognostic factor of relapse in low-grade, early-stage EEC. Two-hundred and fifty-eight cases were selected according to the following inclusion criteria: (i) endometrioid endometrial carcinomas, (ii) grade 1 or 2 with (iii) FIGO stage I or II, and (iv) clinical follow-up. Slides were reviewed to annotate the myoinvasive pattern present in each case (infiltrative glands, microcystic, elongated and fragmented –MELF-, broad front, adenomyosis-like and adenoma malignum). Microsatellite instability was studied by immunoexpression of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6). There were 29 recurrences (11.2%) among the 258 cases analysed. A predominant broad front myoinvasive pattern was significantly associated with tumour relapse (p = 0.003). The presence of a pattern of infiltrative glands (p = 0.001) and microsatellite instability (p = 0.004) were associated with lower disease-free survival, without having an impact on overall survival. Our observations suggest the potential value of the pattern of myoinvasion as a prognostic factor in low-grade, early-stage endometrioid endometrial carcinoma. |
format | Online Article Text |
id | pubmed-6966575 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69665752020-01-27 Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma Ruz-Caracuel, Ignacio Ramón-Patino, Jorge L López-Janeiro, Álvaro Yébenes, Laura Berjón, Alberto Hernández, Alicia Gallego, Alejandro Heredia-Soto, Victoria Mendiola, Marta Redondo, Andrés Peláez-García, Alberto Hardisson, David Cancers (Basel) Article Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive patterns as a prognostic factor of relapse in low-grade, early-stage EEC. Two-hundred and fifty-eight cases were selected according to the following inclusion criteria: (i) endometrioid endometrial carcinomas, (ii) grade 1 or 2 with (iii) FIGO stage I or II, and (iv) clinical follow-up. Slides were reviewed to annotate the myoinvasive pattern present in each case (infiltrative glands, microcystic, elongated and fragmented –MELF-, broad front, adenomyosis-like and adenoma malignum). Microsatellite instability was studied by immunoexpression of mismatch repair proteins (MLH1, PMS2, MSH2, and MSH6). There were 29 recurrences (11.2%) among the 258 cases analysed. A predominant broad front myoinvasive pattern was significantly associated with tumour relapse (p = 0.003). The presence of a pattern of infiltrative glands (p = 0.001) and microsatellite instability (p = 0.004) were associated with lower disease-free survival, without having an impact on overall survival. Our observations suggest the potential value of the pattern of myoinvasion as a prognostic factor in low-grade, early-stage endometrioid endometrial carcinoma. MDPI 2019-11-22 /pmc/articles/PMC6966575/ /pubmed/31766622 http://dx.doi.org/10.3390/cancers11121845 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ruz-Caracuel, Ignacio Ramón-Patino, Jorge L López-Janeiro, Álvaro Yébenes, Laura Berjón, Alberto Hernández, Alicia Gallego, Alejandro Heredia-Soto, Victoria Mendiola, Marta Redondo, Andrés Peláez-García, Alberto Hardisson, David Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma |
title | Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma |
title_full | Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma |
title_fullStr | Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma |
title_full_unstemmed | Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma |
title_short | Myoinvasive Pattern as a Prognostic Marker in Low-Grade, Early-Stage Endometrioid Endometrial Carcinoma |
title_sort | myoinvasive pattern as a prognostic marker in low-grade, early-stage endometrioid endometrial carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966575/ https://www.ncbi.nlm.nih.gov/pubmed/31766622 http://dx.doi.org/10.3390/cancers11121845 |
work_keys_str_mv | AT ruzcaracuelignacio myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT ramonpatinojorgel myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT lopezjaneiroalvaro myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT yebeneslaura myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT berjonalberto myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT hernandezalicia myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT gallegoalejandro myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT herediasotovictoria myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT mendiolamarta myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT redondoandres myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT pelaezgarciaalberto myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma AT hardissondavid myoinvasivepatternasaprognosticmarkerinlowgradeearlystageendometrioidendometrialcarcinoma |