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The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT Signaling

Glioblastoma is a highly aggressive and lethal brain tumor, with limited treatment options. Abnormal activation of the neddylation pathway is observed in glioblastoma, and the NEDD8-activating enzyme (NAE) inhibitor, MLN4924, was previously shown to be effective in glioblastoma cell line models. How...

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Detalles Bibliográficos
Autores principales:	Han, Suji, Shin, Hyemi, Oh, Jeong-Woo, Oh, Yun Jeong, Her, Nam-Gu, Nam, Do-Hyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966592/ https://www.ncbi.nlm.nih.gov/pubmed/31771104 http://dx.doi.org/10.3390/cancers11121849

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