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UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium

Sunscreens today contain several synthetic UV (Ultraviolet) filter molecules to protect the skin epidermis from UV radiation damage. However, these molecules may create several negative effects on human skin. Due to this condition, there is an increase in the development of natural products to repla...

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Autores principales: Prasedya, Eka Sunarwidhi, Syafitri, Sundari Maulinda, Geraldine, Brigitta A. F. D., Hamdin, Candra Dwipayana, Frediansyah, Andri, Miyake, Masao, Kobayashi, Daisuke, Hazama, Akihiro, Sunarpi, Haji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966596/
https://www.ncbi.nlm.nih.gov/pubmed/31569807
http://dx.doi.org/10.3390/biomedicines7040077
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author Prasedya, Eka Sunarwidhi
Syafitri, Sundari Maulinda
Geraldine, Brigitta A. F. D.
Hamdin, Candra Dwipayana
Frediansyah, Andri
Miyake, Masao
Kobayashi, Daisuke
Hazama, Akihiro
Sunarpi, Haji
author_facet Prasedya, Eka Sunarwidhi
Syafitri, Sundari Maulinda
Geraldine, Brigitta A. F. D.
Hamdin, Candra Dwipayana
Frediansyah, Andri
Miyake, Masao
Kobayashi, Daisuke
Hazama, Akihiro
Sunarpi, Haji
author_sort Prasedya, Eka Sunarwidhi
collection PubMed
description Sunscreens today contain several synthetic UV (Ultraviolet) filter molecules to protect the skin epidermis from UV radiation damage. However, these molecules may create several negative effects on human skin. Due to this condition, there is an increase in the development of natural products to replace uses of these synthetic chemicals. Brown macroalgae Sargassum has been recently studied for its photoprotective activities. The purpose of this study is to investigate photoprotective activity of one of most abundant Sargassum species in Lombok coast; Sargassum cristaefolium. Spectrophotometry analysis with UV-VIS revealed the UV spectra absorbing capability of Sargassum cristaefolium (SC) in the UVA spectrum range (314–400 nm). Furthermore, spectrometry analyses with LC-MS revealed the existence of UV absorbing compound MAA-palythene. In correlation, SC ethanol extracts also demonstrate that it could protect DNA from UVA irradiation as analyzed in vitro in HeLa cell model. The effects of SC on UVA exposed-dorsal mice skin have also shown interesting results, as mice pretreated with SC before UVA exposure showed protective activity on the epidermal integrity similar as positive control. Whereas, UV exposed mice without SC or commercial products resulted in increased epidermal thickness, which is the common parameter of skin photoaging. In addition, pretreated mice with SC also show protective effects in the formation of collagen connective tissues. Overall, current results show promising photoprotective activity of SC against UV radiation. More advanced investigations of SC as a potential photoprotective agent would be reasonable for development of macroalgae-based natural skin protection products.
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spelling pubmed-69665962020-02-04 UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium Prasedya, Eka Sunarwidhi Syafitri, Sundari Maulinda Geraldine, Brigitta A. F. D. Hamdin, Candra Dwipayana Frediansyah, Andri Miyake, Masao Kobayashi, Daisuke Hazama, Akihiro Sunarpi, Haji Biomedicines Article Sunscreens today contain several synthetic UV (Ultraviolet) filter molecules to protect the skin epidermis from UV radiation damage. However, these molecules may create several negative effects on human skin. Due to this condition, there is an increase in the development of natural products to replace uses of these synthetic chemicals. Brown macroalgae Sargassum has been recently studied for its photoprotective activities. The purpose of this study is to investigate photoprotective activity of one of most abundant Sargassum species in Lombok coast; Sargassum cristaefolium. Spectrophotometry analysis with UV-VIS revealed the UV spectra absorbing capability of Sargassum cristaefolium (SC) in the UVA spectrum range (314–400 nm). Furthermore, spectrometry analyses with LC-MS revealed the existence of UV absorbing compound MAA-palythene. In correlation, SC ethanol extracts also demonstrate that it could protect DNA from UVA irradiation as analyzed in vitro in HeLa cell model. The effects of SC on UVA exposed-dorsal mice skin have also shown interesting results, as mice pretreated with SC before UVA exposure showed protective activity on the epidermal integrity similar as positive control. Whereas, UV exposed mice without SC or commercial products resulted in increased epidermal thickness, which is the common parameter of skin photoaging. In addition, pretreated mice with SC also show protective effects in the formation of collagen connective tissues. Overall, current results show promising photoprotective activity of SC against UV radiation. More advanced investigations of SC as a potential photoprotective agent would be reasonable for development of macroalgae-based natural skin protection products. MDPI 2019-09-27 /pmc/articles/PMC6966596/ /pubmed/31569807 http://dx.doi.org/10.3390/biomedicines7040077 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Prasedya, Eka Sunarwidhi
Syafitri, Sundari Maulinda
Geraldine, Brigitta A. F. D.
Hamdin, Candra Dwipayana
Frediansyah, Andri
Miyake, Masao
Kobayashi, Daisuke
Hazama, Akihiro
Sunarpi, Haji
UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium
title UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium
title_full UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium
title_fullStr UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium
title_full_unstemmed UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium
title_short UVA Photoprotective Activity of Brown Macroalgae Sargassum cristafolium
title_sort uva photoprotective activity of brown macroalgae sargassum cristafolium
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966596/
https://www.ncbi.nlm.nih.gov/pubmed/31569807
http://dx.doi.org/10.3390/biomedicines7040077
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