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MicroRNAs in Animal Models of HCC

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Molecular heterogeneity and absence of biomarkers for patient allocation to the best therapeutic option contribute to poor prognosis of advanced stages. Aberrant microRNA (miRNA) expression is associated with HCC...

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Autores principales: Fornari, Francesca, Gramantieri, Laura, Callegari, Elisa, Shankaraiah, Ram C., Piscaglia, Fabio, Negrini, Massimo, Giovannini, Catia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966618/
https://www.ncbi.nlm.nih.gov/pubmed/31805631
http://dx.doi.org/10.3390/cancers11121906
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author Fornari, Francesca
Gramantieri, Laura
Callegari, Elisa
Shankaraiah, Ram C.
Piscaglia, Fabio
Negrini, Massimo
Giovannini, Catia
author_facet Fornari, Francesca
Gramantieri, Laura
Callegari, Elisa
Shankaraiah, Ram C.
Piscaglia, Fabio
Negrini, Massimo
Giovannini, Catia
author_sort Fornari, Francesca
collection PubMed
description Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Molecular heterogeneity and absence of biomarkers for patient allocation to the best therapeutic option contribute to poor prognosis of advanced stages. Aberrant microRNA (miRNA) expression is associated with HCC development and progression and influences drug resistance. Therefore, miRNAs have been assayed as putative biomarkers and therapeutic targets. miRNA-based therapeutic approaches demonstrated safety profiles and antitumor efficacy in HCC animal models; nevertheless, caution should be used when transferring preclinical findings to the clinics, due to possible molecular inconsistency between animal models and the heterogeneous pattern of the human disease. In this context, models with defined genetic and molecular backgrounds might help to identify novel therapeutic options for specific HCC subgroups. In this review, we describe rodent models of HCC, emphasizing their representativeness with the human pathology and their usefulness as preclinical tools for assessing miRNA-based therapeutic strategies.
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spelling pubmed-69666182020-02-04 MicroRNAs in Animal Models of HCC Fornari, Francesca Gramantieri, Laura Callegari, Elisa Shankaraiah, Ram C. Piscaglia, Fabio Negrini, Massimo Giovannini, Catia Cancers (Basel) Review Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality. Molecular heterogeneity and absence of biomarkers for patient allocation to the best therapeutic option contribute to poor prognosis of advanced stages. Aberrant microRNA (miRNA) expression is associated with HCC development and progression and influences drug resistance. Therefore, miRNAs have been assayed as putative biomarkers and therapeutic targets. miRNA-based therapeutic approaches demonstrated safety profiles and antitumor efficacy in HCC animal models; nevertheless, caution should be used when transferring preclinical findings to the clinics, due to possible molecular inconsistency between animal models and the heterogeneous pattern of the human disease. In this context, models with defined genetic and molecular backgrounds might help to identify novel therapeutic options for specific HCC subgroups. In this review, we describe rodent models of HCC, emphasizing their representativeness with the human pathology and their usefulness as preclinical tools for assessing miRNA-based therapeutic strategies. MDPI 2019-12-01 /pmc/articles/PMC6966618/ /pubmed/31805631 http://dx.doi.org/10.3390/cancers11121906 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Fornari, Francesca
Gramantieri, Laura
Callegari, Elisa
Shankaraiah, Ram C.
Piscaglia, Fabio
Negrini, Massimo
Giovannini, Catia
MicroRNAs in Animal Models of HCC
title MicroRNAs in Animal Models of HCC
title_full MicroRNAs in Animal Models of HCC
title_fullStr MicroRNAs in Animal Models of HCC
title_full_unstemmed MicroRNAs in Animal Models of HCC
title_short MicroRNAs in Animal Models of HCC
title_sort micrornas in animal models of hcc
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966618/
https://www.ncbi.nlm.nih.gov/pubmed/31805631
http://dx.doi.org/10.3390/cancers11121906
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