Cargando…

Impact of ATM and DNA-PK Inhibition on Gene Expression and Individual Response of Human Lymphocytes to Mixed Beams of Alpha Particles and X-Rays

Accumulating evidence suggests a synergistic effect in cells simultaneously exposed to different types of clustered and dispersed DNA damage. We aimed to analyse the effect of mixed beams of alpha particles and X-rays (1:1 dose of each) on DNA damage response genes in human peripheral blood lymphocy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cheng, Lei, Brzozowska-Wardecka, Beata, Lisowska, Halina, Wojcik, Andrzej, Lundholm, Lovisa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966634/ https://www.ncbi.nlm.nih.gov/pubmed/31847107 http://dx.doi.org/10.3390/cancers11122013

Ejemplares similares

Simultaneous induction of dispersed and clustered DNA lesions compromises DNA damage response in human peripheral blood lymphocytes
por: Cheng, Lei, et al.
Publicado: (2018)

The order of sequential exposure of U2OS cells to gamma and alpha radiation influences the formation and decay dynamics of NBS1 foci
por: Tartas, Adrianna, et al.
Publicado: (2023)

Cisplatin Reduces the Frequencies of Radiotherapy-Induced Micronuclei in Peripheral Blood Lymphocytes of Patients with Gynaecological Cancer: Possible Implications for the Risk of Second Malignant Neoplasms
por: Węgierek-Ciuk, Aneta, et al.
Publicado: (2021)

Live Dynamics of 53BP1 Foci Following Simultaneous Induction of Clustered and Dispersed DNA Damage in U2OS Cells
por: Sollazzo, Alice, et al.
Publicado: (2018)

Gamma-H2AX foci in cells exposed to a mixed beam of X-rays and alpha particles
por: Staaf, Elina, et al.
Publicado: (2012)

Alpha Radiation as a Way to Target Heterochromatic and Gamma Radiation-Exposed Breast Cancer Cells
por: Svetličič, Maja, et al.
Publicado: (2020)

Biological effectiveness of very high gamma dose rate and its implication for radiological protection
por: Olofsson, Dante, et al.
Publicado: (2020)

Fluorescence in situ hybridisation for interphase chromosomal aberration-based biological dosimetry
por: Meher, Prabodha Kumar, et al.
Publicado: (2023)

Freeware tool for analysing numbers and sizes of cell colonies
por: Brzozowska, Beata, et al.
Publicado: (2019)

The DNA damage response to radiological imaging: from ROS and γH2AX foci induction to gene expression responses in vivo
por: López-Riego, Milagrosa, et al.
Publicado: (2023)

Radiation-induced DNA damage and repair in human γδ and αβ T-lymphocytes analysed by the alkaline comet assay
por: Lisowska, Halina, et al.
Publicado: (2010)

Analysis of the Applicability of microRNAs in Peripheral Blood Leukocytes as Biomarkers of Sensitivity and Exposure to Fractionated Radiotherapy towards Breast Cancer
por: Marczyk, Michal, et al.
Publicado: (2021)

Resistance to DNA-damaging treatment in non-small cell lung cancer tumor-initiating cells involves reduced DNA-PK/ATM activation and diminished cell cycle arrest
por: Lundholm, L, et al.
Publicado: (2013)

Inhibition of DNA-PK activity sensitizes A549 cells to X-ray irradiation by inducing the ATM-dependent DNA damage response
por: Yang, Lina, et al.
Publicado: (2018)

Impact of fractionated cisplatin and radiation treatment on cell growth and accumulation of DNA damage in two normal cell types differing in origin
por: Akuwudike, Pamela, et al.
Publicado: (2023)

HER2-positive breast cancer that resists therapeutic drugs and ionizing radiation releases sphingomyelin-based molecules to circulating blood serum
por: Monzen, Satoru, et al.
Publicado: (2020)

Comparative analysis of three functional predictive assays in lymphocytes of patients with breast and gynaecological cancer treated by radiotherapy
por: Padjas, Anna, et al.
Publicado: (2012)

Ionizing radiation-induced XRCC4 phosphorylation is mediated through ATM in addition to DNA-PK
por: IMAMICHI, Shoji, et al.
Publicado: (2014)

Both ATM and DNA-PK Are the Main Regulators of HIV-1 Post-Integrational DNA Repair
por: Anisenko, Andrey, et al.
Publicado: (2023)

Cell Type-Specific Patterns in the Accumulation of DNA Damage Following Multifractional Radiation Exposure
por: Akuwudike, Pamela, et al.
Publicado: (2022)

Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress
por: Liu, Shengqin, et al.
Publicado: (2012)

Inhibition of DNA Repair by Inappropriate Activation of ATM, PARP, and DNA-PK with the Drug Agonist AsiDNA
por: Berthault, Nathalie, et al.
Publicado: (2022)

Clustered DNA damage induces pan-nuclear H2AX phosphorylation mediated by ATM and DNA–PK
por: Meyer, Barbara, et al.
Publicado: (2013)

ATM phosphorylates the FATC domain of DNA-PK(cs) at threonine 4102 to promote non-homologous end joining
por: Lu, Huiming, et al.
Publicado: (2023)

DNA-PK, ATM and ATR collaboratively regulate p53-RPA interaction to facilitate homologous recombination DNA repair
por: Serrano, Moises A., et al.
Publicado: (2012)

Beyond the Trinity of ATM, ATR, and DNA-PK: Multiple Kinases Shape the DNA Damage Response in Concert With RNA Metabolism
por: Burger, Kaspar, et al.
Publicado: (2019)

Production of medical radioisotopes with an alpha particle beam
por: Alic, Adin
Publicado: (2021)

ATM-Mediated Transcriptional and Developmental Responses to γ-rays in Arabidopsis
por: Ricaud, Lilian, et al.
Publicado: (2007)

Rare Germline Variants in ATM Are Associated with Chronic Lymphocytic Leukemia
por: Tiao, Grace, et al.
Publicado: (2017)

$\alpha$-particle induced $\gamma$-ray transitions in light elements
por: Heaton, R K, et al.
Publicado: (1996)

AIF-mediated caspase-independent necroptosis requires ATM and DNA-PK-induced histone H2AX Ser139 phosphorylation
por: Baritaud, M, et al.
Publicado: (2012)

High Fidelity Deep Sequencing Reveals No Effect of ATM, ATR, and DNA-PK Cellular DNA Damage Response Pathways on Adenovirus Mutation Rate
por: Risso-Ballester, Jennifer, et al.
Publicado: (2019)

PARP Inhibitor Olaparib Causes No Potentiation of the Bleomycin Effect in VERO Cells, Even in the Presence of Pooled ATM, DNA-PK, and LigIV Inhibitors
por: Perini, Valentina, et al.
Publicado: (2020)

Live-cell tracking of γ-H2AX kinetics reveals the distinct modes of ATM and DNA-PK in the immediate response to DNA damage
por: Trakarnphornsombat, Watanya, et al.
Publicado: (2023)

Editorial: DNA damage response in the context of chromatin
por: Zong, Dali, et al.
Publicado: (2023)

Characterization of prickle isoform-specific pk (pk1) and pk (sple1) mutations in Drosophila melanogaster
por: Lilienthal, Anthony J, et al.
Publicado: (2022)

ATM function and its relationship with ATM gene mutations in chronic lymphocytic leukemia with the recurrent deletion (11q22.3-23.2)
por: Jiang, Y, et al.
Publicado: (2016)

Hypothermia differentially modulates the formation and decay of NBS1, γH2AX and 53BP1 foci in U2OS cells exposed to gamma radiation
por: Płódowska, Magdalena, et al.
Publicado: (2022)

Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes
por: Huang, Ching-Yu, et al.
Publicado: (2007)

$\alpha$-particle induced high-energy $\gamma$-ray yields from light elements
por: Heaton, R K, et al.
Publicado: (1995)

Cannot write session to /tmp/vufind_sessions/sess_pco1ajueo16121tsm868f56bne