Analysis of PMEPA1 Isoforms (a and b) as Selective Inhibitors of Androgen and TGF-β Signaling Reveals Distinct Biological and Prognostic Features in Prostate Cancer

Dysfunctions of androgen/TGF-β signaling play important roles in prostate tumorigenesis. Prostate Transmembrane Protein Androgen Induced 1 (PMEPA1) inhibits androgen and TGF-β signaling via a negative feedback loop. The loss of PMEPA1 confers resistance to androgen signaling inhibitors and promotes...

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Detalles Bibliográficos
Autores principales: Sharad, Shashwat, Sztupinszki, Zsófia M., Chen, Yongmei, Kuo, Claire, Ravindranath, Lakshmi, Szallasi, Zoltan, Petrovics, Gyorgy, Sreenath, Taduru L., Dobi, Albert, Rosner, Inger L., Srinivasan, Alagarsamy, Srivastava, Shiv, Cullen, Jennifer, Li, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966662/
https://www.ncbi.nlm.nih.gov/pubmed/31842254
http://dx.doi.org/10.3390/cancers11121995

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