High Somatic Mutation and Neoantigen Burden Do Not Correlate with Decreased Progression-Free Survival in HCC Patients not Undergoing Immunotherapy

Cancer genome instability leads to accumulation of mutations which may result into tumor-specific mutated “neoantigens”, not be affected by central T-cell tolerance. Such neoantigens are considered the optimal target for the patient’s anti-tumor T cell immunity as well as for personalized cancer imm...

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Detalles Bibliográficos
Autores principales: Mauriello, Angela, Zeuli, Roberta, Cavalluzzo, Beatrice, Petrizzo, Annacarmen, Tornesello, Maria Lina, Buonaguro, Franco M., Ceccarelli, Michele, Tagliamonte, Maria, Buonaguro, Luigi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966682/
https://www.ncbi.nlm.nih.gov/pubmed/31756926
http://dx.doi.org/10.3390/cancers11121824

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966682/
https://www.ncbi.nlm.nih.gov/pubmed/31756926
http://dx.doi.org/10.3390/cancers11121824

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