A systematic survey of randomised trials that stopped early for reasons of futility

BACKGROUND: Randomised trial protocols may incorporate interim analyses, with the potential to stop the study for futility if early data show insufficient promise of a treatment benefit. Previously, we have shown that this approach will theoretically lead to mis-estimation of the treatment effect. W...

Descripción completa

Detalles Bibliográficos
Autores principales: Walter, S. D., Han, H., Guyatt, G. H., Bassler, D., Bhatnagar, N., Gloy, V., Schandelmaier, S., Briel, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966801/
https://www.ncbi.nlm.nih.gov/pubmed/31948397
http://dx.doi.org/10.1186/s12874-020-0899-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966801/
https://www.ncbi.nlm.nih.gov/pubmed/31948397
http://dx.doi.org/10.1186/s12874-020-0899-1

Ejemplares similares