Inverted Binding of Non-natural Substrates in Strictosidine Synthase Leads to a Switch of Stereochemical Outcome in Enzyme-Catalyzed Pictet–Spengler Reactions

[Image: see text] The Pictet–Spengler reaction is a valuable route to 1,2,3,4-tetrahydro-β-carboline (THBC) and isoquinoline scaffolds found in many important pharmaceuticals. Strictosidine synthase (STR) catalyzes the Pictet–Spengler condensation of tryptamine and the aldehyde secologanin to give (...

Descripción completa

Detalles Bibliográficos
Autores principales: Eger, Elisabeth, Simon, Adam, Sharma, Mahima, Yang, Song, Breukelaar, Willem B., Grogan, Gideon, Houk, K. N., Kroutil, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966912/
https://www.ncbi.nlm.nih.gov/pubmed/31909617
http://dx.doi.org/10.1021/jacs.9b08704

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966912/
https://www.ncbi.nlm.nih.gov/pubmed/31909617
http://dx.doi.org/10.1021/jacs.9b08704

Ejemplares similares