Apparent Lack of BRAF(V600E) Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8(+) T Cells in Langerhans Cell Histiocytosis

Langerhans Cell Histiocytosis (LCH) is a neoplastic disorder of hematopoietic origin characterized by inflammatory lesions containing clonal histiocytes (LCH-cells) intermixed with various immune cells, including T cells. In 50–60% of LCH-patients, the somatic BRAF(V600E) driver mutation, which is c...

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Detalles Bibliográficos
Autores principales: Kemps, Paul G., Zondag, Timo C., Steenwijk, Eline C., Andriessen, Quirine, Borst, Jelske, Vloemans, Sandra, Roelen, Dave L., Voortman, Lenard M., Verdijk, Robert M., van Noesel, Carel J. M., Cleven, Arjen H. G., Hawkins, Cynthia, Lang, Veronica, de Ru, Arnoud H., Janssen, George M. C., Haasnoot, Geert W., Franken, Kees L. M. C., van Eijk, Ronald, Solleveld-Westerink, Nienke, van Wezel, Tom, Egeler, R. Maarten, Beishuizen, Auke, van Laar, Jan A. M., Abla, Oussama, van den Bos, Cor, van Veelen, Peter A., van Halteren, Astrid G. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967030/
https://www.ncbi.nlm.nih.gov/pubmed/31998317
http://dx.doi.org/10.3389/fimmu.2019.03045

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