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Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor

Mediastinal nonseminomatous germ cell tumor (NSGCT) is rare. NSGCT shows excellent response to cisplatin-based chemotherapy. However, some tumors continue to enlarge despite normal tumor markers after chemotherapy, a rare condition called growing teratoma syndrome (GTS). Recognition of this conditio...

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Autores principales: Diong, Nguk Chai, Dharmaraj, Benedict, Joseph, Cindy Thomas, Sathiamurthy, Narasimman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967146/
https://www.ncbi.nlm.nih.gov/pubmed/32002046
http://dx.doi.org/10.4103/atm.ATM_296_19
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author Diong, Nguk Chai
Dharmaraj, Benedict
Joseph, Cindy Thomas
Sathiamurthy, Narasimman
author_facet Diong, Nguk Chai
Dharmaraj, Benedict
Joseph, Cindy Thomas
Sathiamurthy, Narasimman
author_sort Diong, Nguk Chai
collection PubMed
description Mediastinal nonseminomatous germ cell tumor (NSGCT) is rare. NSGCT shows excellent response to cisplatin-based chemotherapy. However, some tumors continue to enlarge despite normal tumor markers after chemotherapy, a rare condition called growing teratoma syndrome (GTS). Recognition of this condition is imperative for prompt surgical resection to prevent further cardiopulmonary compression and to improve survival. Multidisciplinary team meeting is important for perioperative preparation and care to improve the outcome of this high-risk surgery. Here, we report two cases of mediastinal GTS and underwent surgical resection, of which one died of pericardial decompression syndrome and the other is well.
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spelling pubmed-69671462020-01-30 Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor Diong, Nguk Chai Dharmaraj, Benedict Joseph, Cindy Thomas Sathiamurthy, Narasimman Ann Thorac Med Case Report Mediastinal nonseminomatous germ cell tumor (NSGCT) is rare. NSGCT shows excellent response to cisplatin-based chemotherapy. However, some tumors continue to enlarge despite normal tumor markers after chemotherapy, a rare condition called growing teratoma syndrome (GTS). Recognition of this condition is imperative for prompt surgical resection to prevent further cardiopulmonary compression and to improve survival. Multidisciplinary team meeting is important for perioperative preparation and care to improve the outcome of this high-risk surgery. Here, we report two cases of mediastinal GTS and underwent surgical resection, of which one died of pericardial decompression syndrome and the other is well. Wolters Kluwer - Medknow 2020 2020-01-02 /pmc/articles/PMC6967146/ /pubmed/32002046 http://dx.doi.org/10.4103/atm.ATM_296_19 Text en Copyright: © 2020 Annals of Thoracic Medicine http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Case Report
Diong, Nguk Chai
Dharmaraj, Benedict
Joseph, Cindy Thomas
Sathiamurthy, Narasimman
Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
title Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
title_full Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
title_fullStr Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
title_full_unstemmed Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
title_short Growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
title_sort growing teratoma syndrome of mediastinal nonseminomatous germ cell tumor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967146/
https://www.ncbi.nlm.nih.gov/pubmed/32002046
http://dx.doi.org/10.4103/atm.ATM_296_19
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