USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination

Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent Snail degradation by regulating the ubiquitination-mediate...

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Autores principales: Cai, Jiali, Li, Mengying, Wang, Xiang, Li, Lei, Li, Qi, Hou, Zhaoyuan, Jia, Hao, Liu, Shiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967296/
https://www.ncbi.nlm.nih.gov/pubmed/31998374
http://dx.doi.org/10.3389/fgene.2019.01324
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author Cai, Jiali
Li, Mengying
Wang, Xiang
Li, Lei
Li, Qi
Hou, Zhaoyuan
Jia, Hao
Liu, Shiyuan
author_facet Cai, Jiali
Li, Mengying
Wang, Xiang
Li, Lei
Li, Qi
Hou, Zhaoyuan
Jia, Hao
Liu, Shiyuan
author_sort Cai, Jiali
collection PubMed
description Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent Snail degradation by regulating the ubiquitination-mediated hydrolysis process. Our studies demonstrate that a deubiquitinating enzyme (DUB) family member, USP37, can deubiquitinate Snail and prevent degradation of Snail. USP37 is co-localized with Snail in the nucleus. Biologically, upregulated expression of USP37 promotes lung cancer cell migration, while depletion of Snail abolishes the effect of USP37. These data demonstrate that USP37 is a Snail-specific deubiquitinase and also indicate a potential therapeutic target for metastasis.
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spelling pubmed-69672962020-01-29 USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination Cai, Jiali Li, Mengying Wang, Xiang Li, Lei Li, Qi Hou, Zhaoyuan Jia, Hao Liu, Shiyuan Front Genet Genetics Snail is a prominent epithelial–mesenchymal transition (EMT) transcription factor and promotes metastasis. However, Snail protein is unstable and is quickly degraded through ubiquitination-mediated proteasome pathway. Deubiquitinases prevent Snail degradation by regulating the ubiquitination-mediated hydrolysis process. Our studies demonstrate that a deubiquitinating enzyme (DUB) family member, USP37, can deubiquitinate Snail and prevent degradation of Snail. USP37 is co-localized with Snail in the nucleus. Biologically, upregulated expression of USP37 promotes lung cancer cell migration, while depletion of Snail abolishes the effect of USP37. These data demonstrate that USP37 is a Snail-specific deubiquitinase and also indicate a potential therapeutic target for metastasis. Frontiers Media S.A. 2020-01-10 /pmc/articles/PMC6967296/ /pubmed/31998374 http://dx.doi.org/10.3389/fgene.2019.01324 Text en Copyright © 2020 Cai, Li, Wang, Li, Li, Hou, Jia and Liu http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Genetics
Cai, Jiali
Li, Mengying
Wang, Xiang
Li, Lei
Li, Qi
Hou, Zhaoyuan
Jia, Hao
Liu, Shiyuan
USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination
title USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination
title_full USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination
title_fullStr USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination
title_full_unstemmed USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination
title_short USP37 Promotes Lung Cancer Cell Migration by Stabilizing Snail Protein via Deubiquitination
title_sort usp37 promotes lung cancer cell migration by stabilizing snail protein via deubiquitination
topic Genetics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967296/
https://www.ncbi.nlm.nih.gov/pubmed/31998374
http://dx.doi.org/10.3389/fgene.2019.01324
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