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A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus

BACKGROUND: Lichen planus is a T-cell-mediated autoimmune disease, in which CD8+ T-cells releases the cytokines such as tumor necrosis factor-alpha and interleukin-12 disrupting basement membrane integrity. Treatment modalities were directed toward the relief in signs and symptoms and preventing rec...

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Autores principales: Suvarna, Chintada, Chaitanya, Nallan CSK, Ameer, Shaik, Mannava, Himabindu, Bontala, Parinita, Alyami, Jabar Sadan, Samreen, Humaira, Kondapaneni, Jayasurya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967345/
https://www.ncbi.nlm.nih.gov/pubmed/32002387
http://dx.doi.org/10.4103/ijabmr.IJABMR_138_19
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author Suvarna, Chintada
Chaitanya, Nallan CSK
Ameer, Shaik
Mannava, Himabindu
Bontala, Parinita
Alyami, Jabar Sadan
Samreen, Humaira
Kondapaneni, Jayasurya
author_facet Suvarna, Chintada
Chaitanya, Nallan CSK
Ameer, Shaik
Mannava, Himabindu
Bontala, Parinita
Alyami, Jabar Sadan
Samreen, Humaira
Kondapaneni, Jayasurya
author_sort Suvarna, Chintada
collection PubMed
description BACKGROUND: Lichen planus is a T-cell-mediated autoimmune disease, in which CD8+ T-cells releases the cytokines such as tumor necrosis factor-alpha and interleukin-12 disrupting basement membrane integrity. Treatment modalities were directed toward the relief in signs and symptoms and preventing recurrences. Zinc activates caspase-3 and DNA fragmentation, resulting in the apoptosis of keratinocytes. Prevention of matrix metalloproteinases1 (MMP1) activation, inhibits the Tcell accumulation in oral lichen planus (OLP) and by inhibiting MMP9, prevents the cleavage of collagen resulting in maintaining the integrity of the basement membrane. OBJECTIVES: The main objective of the study is to compare the efficacy of oral zinc 50 mg and 0.1% triamcinolone Orabase with 0.1% triamcinolone Orabase alone on the healing process of symptomatic OLP. MATERIALS AND METHODS: A total of forty participants were randomly categorized into two groups: Group A and Group B with 20 patients with OLP and having symptoms of burning sensation. Group A patients had received 0.1% triamcinolone Orabase twice daily application. Group B patients had provided with oral zinc 50 mg and 0.1% triamcinolone Orabase twice daily for 8 weeks. The follow-up period for both the groups was 6 months. Lesional size was measured by Thongprasom scale and burning sensation was assessed by visual analog scale at each visit till the cessation of treatment. RESULTS: There was decrease in the burning sensation and lesional size from the first visit to follow-up period which was statistically significant in both groups (P = 0.000). CONCLUSION: Oral zinc therapy was adjunctive in reducing the burning sensation and lesional size in the symptomatic OLP.
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spelling pubmed-69673452020-01-30 A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus Suvarna, Chintada Chaitanya, Nallan CSK Ameer, Shaik Mannava, Himabindu Bontala, Parinita Alyami, Jabar Sadan Samreen, Humaira Kondapaneni, Jayasurya Int J Appl Basic Med Res Original Article BACKGROUND: Lichen planus is a T-cell-mediated autoimmune disease, in which CD8+ T-cells releases the cytokines such as tumor necrosis factor-alpha and interleukin-12 disrupting basement membrane integrity. Treatment modalities were directed toward the relief in signs and symptoms and preventing recurrences. Zinc activates caspase-3 and DNA fragmentation, resulting in the apoptosis of keratinocytes. Prevention of matrix metalloproteinases1 (MMP1) activation, inhibits the Tcell accumulation in oral lichen planus (OLP) and by inhibiting MMP9, prevents the cleavage of collagen resulting in maintaining the integrity of the basement membrane. OBJECTIVES: The main objective of the study is to compare the efficacy of oral zinc 50 mg and 0.1% triamcinolone Orabase with 0.1% triamcinolone Orabase alone on the healing process of symptomatic OLP. MATERIALS AND METHODS: A total of forty participants were randomly categorized into two groups: Group A and Group B with 20 patients with OLP and having symptoms of burning sensation. Group A patients had received 0.1% triamcinolone Orabase twice daily application. Group B patients had provided with oral zinc 50 mg and 0.1% triamcinolone Orabase twice daily for 8 weeks. The follow-up period for both the groups was 6 months. Lesional size was measured by Thongprasom scale and burning sensation was assessed by visual analog scale at each visit till the cessation of treatment. RESULTS: There was decrease in the burning sensation and lesional size from the first visit to follow-up period which was statistically significant in both groups (P = 0.000). CONCLUSION: Oral zinc therapy was adjunctive in reducing the burning sensation and lesional size in the symptomatic OLP. Wolters Kluwer - Medknow 2020 2020-01-03 /pmc/articles/PMC6967345/ /pubmed/32002387 http://dx.doi.org/10.4103/ijabmr.IJABMR_138_19 Text en Copyright: © 2020 International Journal of Applied and Basic Medical Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Suvarna, Chintada
Chaitanya, Nallan CSK
Ameer, Shaik
Mannava, Himabindu
Bontala, Parinita
Alyami, Jabar Sadan
Samreen, Humaira
Kondapaneni, Jayasurya
A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus
title A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus
title_full A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus
title_fullStr A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus
title_full_unstemmed A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus
title_short A Comparative Evaluation on the Effect of Oral Zinc 50 mg with or without 0.1% Triamcinolone Orabase on Oral Lichen Planus
title_sort comparative evaluation on the effect of oral zinc 50 mg with or without 0.1% triamcinolone orabase on oral lichen planus
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967345/
https://www.ncbi.nlm.nih.gov/pubmed/32002387
http://dx.doi.org/10.4103/ijabmr.IJABMR_138_19
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