Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies–Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites

We have demonstrated previously that amino-artemisinins including artemiside and artemisone in which an amino group replaces the oxygen-bearing substituents attached to C-10 of the current clinical artemisinin derivatives dihydroartemisinin (DHA), artemether and artesunate, display potent activities...

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Detalles Bibliográficos
Autores principales: Wong, Ho Ning, Padín-Irizarry, Vivian, van der Watt, Mariëtte E., Reader, Janette, Liebenberg, Wilna, Wiesner, Lubbe, Smith, Peter, Eribez, Korina, Winzeler, Elizabeth A., Kyle, Dennis E., Birkholtz, Lyn-Marie, Coertzen, Dina, Haynes, Richard K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6967409/
https://www.ncbi.nlm.nih.gov/pubmed/31998692
http://dx.doi.org/10.3389/fchem.2019.00901

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