Design, synthesis, in vitro and in vivo evaluation of benzylpiperidine-linked 1,3-dimethylbenzimidazolinones as cholinesterase inhibitors against Alzheimer’s disease

Cholinesterase inhibitor plays an important role in the treatment of patients with Alzheimer’s disease (AD). Herein, we report the medicinal chemistry efforts leading to a new series of 1,3-dimethylbenzimidazolinone derivatives. Among the synthesised compounds, 15b and 15j showed submicromolar IC(50...

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Detalles Bibliográficos
Autores principales: Mo, Jun, Chen, Tingkai, Yang, Hongyu, Guo, Yan, Li, Qi, Qiao, Yuting, Lin, Hongzhi, Feng, Feng, Liu, Wenyuan, Chen, Yao, Liu, Zongliang, Sun, Haopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968383/
https://www.ncbi.nlm.nih.gov/pubmed/31856607
http://dx.doi.org/10.1080/14756366.2019.1699553

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