Design, synthesis, and biological evaluation of novel substituted thiourea derivatives as potential anticancer agents for NSCLC by blocking K-Ras protein-effectors interactions

Mutation of the proto-oncogene K-Ras is one of the most common molecular mechanisms in non-small cell lung cancer. Many drugs for treating lung cancer have been developed, however, due to clinical observed K-Ras mutations, corresponding chemotherapy and targeted therapy for such mutation are not eff...

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Detalles Bibliográficos
Autores principales: Zhang, Yuan, Meng, Xin, Tang, Haikang, Cheng, Minghui, Yang, Fujun, Xu, Wenqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968486/
https://www.ncbi.nlm.nih.gov/pubmed/31851852
http://dx.doi.org/10.1080/14756366.2019.1702653

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