Design, synthesis and biological evaluation of carbohydrate-based sulphonamide derivatives as topical antiglaucoma agents through selective inhibition of carbonic anhydrase II

A series of new carbohydrate-based sulphonamide derivatives were designed, synthesised by employing the so-call ‘sugar-tail’ approach. The compounds were evaluated in vitro against a panel of CAs. Compared to their parent compound p-sulfamoylbenzoic acid, these compounds showed nearly 100-fold impro...

Descripción completa

Detalles Bibliográficos
Autores principales: Hou, Zhuang, Li, Chuanchao, Liu, Yichuang, Zhang, Miao, Wang, Yitong, Fan, Zhanfang, Guo, Chun, Lin, Bin, Liu, Yang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968511/
https://www.ncbi.nlm.nih.gov/pubmed/31865756
http://dx.doi.org/10.1080/14756366.2019.1705293

Ejemplares similares

Ejemplares similares