Novel CDKs inhibitors for the treatment of solid tumour by simultaneously regulating the cell cycle and transcription control

A novel series of cyclin-dependent kinases (CDKs) inhibitors, which play critical roles in the cell cycle control and regulation of cell transcription, were synthesised. A systematic study of enzymatic and cellular assays led to the identification of compound X22 with a nanomolar potency against CDK...

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Detalles Bibliográficos
Autores principales: Wang, Xin, Deng, Kaiyuan, Wang, Cheng, Li, Yao, Wang, Tianqi, Huang, Zhi, Ma, Yakun, Sun, Peiqing, Shi, Yi, Yang, Shengyong, Fan, Yan, Xiang, Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968521/
https://www.ncbi.nlm.nih.gov/pubmed/31899991
http://dx.doi.org/10.1080/14756366.2019.1705290

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