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HIV-1 pseudoviruses constructed in China regulatory laboratory

To better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and circulating recombinant forms. Compared with t...

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Detalles Bibliográficos
Autores principales: Nie, Jianhui, Huang, Weijin, Liu, Qiang, Wang, Youchun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968579/
https://www.ncbi.nlm.nih.gov/pubmed/31859609
http://dx.doi.org/10.1080/22221751.2019.1702479
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author Nie, Jianhui
Huang, Weijin
Liu, Qiang
Wang, Youchun
author_facet Nie, Jianhui
Huang, Weijin
Liu, Qiang
Wang, Youchun
author_sort Nie, Jianhui
collection PubMed
description To better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and circulating recombinant forms. Compared with the standard pseudovirus panels derived from other countries/regions, the Chinese isolates are more susceptible to neutralization by the sera obtained in China, revealing the strain/subtype specificity. Some of these pseudoviruses have already been used for the evaluation of HIV vaccines and drug candidates in Chinese clinical trials. The pseudoviruses panel is widely shared with interested scientists involved in the research and development of vaccines and antiviral drugs against HIV-1 strains prevalent in China.
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spelling pubmed-69685792020-01-31 HIV-1 pseudoviruses constructed in China regulatory laboratory Nie, Jianhui Huang, Weijin Liu, Qiang Wang, Youchun Emerg Microbes Infect Review To better evaluate HIV-1 vaccines and therapeutics, the National Institutes for Food and Drug Control of China developed a panel of HIV-1 pseudoviruses including 462 viral strains derived from China, covering the majority of contemporaneous subtypes and circulating recombinant forms. Compared with the standard pseudovirus panels derived from other countries/regions, the Chinese isolates are more susceptible to neutralization by the sera obtained in China, revealing the strain/subtype specificity. Some of these pseudoviruses have already been used for the evaluation of HIV vaccines and drug candidates in Chinese clinical trials. The pseudoviruses panel is widely shared with interested scientists involved in the research and development of vaccines and antiviral drugs against HIV-1 strains prevalent in China. Taylor & Francis 2019-12-20 /pmc/articles/PMC6968579/ /pubmed/31859609 http://dx.doi.org/10.1080/22221751.2019.1702479 Text en © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Nie, Jianhui
Huang, Weijin
Liu, Qiang
Wang, Youchun
HIV-1 pseudoviruses constructed in China regulatory laboratory
title HIV-1 pseudoviruses constructed in China regulatory laboratory
title_full HIV-1 pseudoviruses constructed in China regulatory laboratory
title_fullStr HIV-1 pseudoviruses constructed in China regulatory laboratory
title_full_unstemmed HIV-1 pseudoviruses constructed in China regulatory laboratory
title_short HIV-1 pseudoviruses constructed in China regulatory laboratory
title_sort hiv-1 pseudoviruses constructed in china regulatory laboratory
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968579/
https://www.ncbi.nlm.nih.gov/pubmed/31859609
http://dx.doi.org/10.1080/22221751.2019.1702479
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