Cargando…

Synthesis and biological evaluation of novel (E)-N'-benzylidene hydrazides as novel c-Met inhibitors through fragment based virtual screening

C-Met plays a crucial role in the development and progression of neoplastic disease. Type II c-Met inhibitors recognise the inactive DFG-out conformation of the kinase, result in better anti-tumour effects due to synergistic effect against the other kinases. According to our previous works, an (E)-N...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liang, Jing-wei, Li, Shi-long, Wang, Shan, Li, Wan-qiu, Meng, Fan-hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968643/ https://www.ncbi.nlm.nih.gov/pubmed/31902266 http://dx.doi.org/10.1080/14756366.2019.1702655

Ejemplares similares

Benzylidene/2-chlorobenzylidene hydrazides: Synthesis, antimicrobial activity, QSAR studies and antiviral evaluation
por: Kumar, Davinder, et al.
Publicado: (2010)

(E)-N′-Benzylidene-p-toluenesulfonohydrazide
por: Mehrabi, Hossein, et al.
Publicado: (2008)

Synthesis Biological Activity of Novel Amino Acid-(N′-Benzoyl) Hydrazide and Amino Acid-(N′-Nicotinoyl) Hydrazide Derivatives
por: Khattab, Sherine N.
Publicado: (2005)

Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase
por: Ruda, Gian Filippo, et al.
Publicado: (2010)

Design, Synthesis and Biological Evaluation of 4-Benzamidobenzoic Acid Hydrazide Derivatives as Novel Soluble Epoxide Hydrolase Inhibitors
por: Rezaee Zavareh, Elham, et al.
Publicado: (2014)

Synthesis and Analgesic Activity of Novel Hydrazide and Hydrazine Derivatives
por: Nassiri Koopaei, Mansur, et al.
Publicado: (2013)

Discovery of Novel Dihydrolipoamide S-Succinyltransferase Inhibitors Based on Fragment Virtual Screening
por: Wei, Chengqian, et al.
Publicado: (2021)

N′-[(E)-Benzylidene]-2-(6-methoxynaphthalen-2-yl)propanohydrazide
por: Mague, Joel T., et al.
Publicado: (2013)

Fragment merging approach for design, synthesis, and biological assessment of urea/acetyl hydrazide clubbed thienopyrimidine derivatives as GSK-3β inhibitors
por: Saleh, Joseph S., et al.
Publicado: (2023)

Design, Synthesis, and Anticancer Evaluation of Novel Tetracaine Hydrazide-Hydrazones
por: Han, M. İhsan, et al.
Publicado: (2023)

Discovery of a Novel Acetylcholinesterase Inhibitor by Fragment-Based Design and Virtual Screening
por: Stavrakov, Georgi, et al.
Publicado: (2021)

Identification of novel CDK2 inhibitors by a multistage virtual screening method based on SVM, pharmacophore and docking model
por: Liang, Jing-Wei, et al.
Publicado: (2019)

Identification of Novel PI3Kδ Selective Inhibitors by SVM-Based Multistage Virtual Screening and Molecular Dynamics Simulations
por: Liang, Jing-wei, et al.
Publicado: (2019)

Design, synthesis, and anticancer evaluation of novel quinoline derivatives of ursolic acid with hydrazide, oxadiazole, and thiadiazole moieties as potent MEK inhibitors
por: Jin, Xiao-Yan, et al.
Publicado: (2019)

Development of substituted benzylidene derivatives as novel dual cholinesterase inhibitors for Alzheimer's treatment
por: Gupta, Shraddha Manish, et al.
Publicado: (2023)

(E,E)-N′-{4-[(2-Benzoylhydrazin-1-ylidene)methyl]benzylidene}benzohydrazide
por: Karimian, Ramin, et al.
Publicado: (2012)

Crystal structure and Hirshfeld surface analysis of (E)-N′-[4-(piperidin-1-yl)benzylidene]arylsulfonohydrazides
por: Pai, Nikhila, et al.
Publicado: (2018)

Virtual screening and experimental validation of novel histone deacetylase inhibitors
por: Huang, Yan-xin, et al.
Publicado: (2016)

Synthesis and Biological Evaluation of Fatty Hydrazides of By-products of Oil Processing Industry
por: Toliwal, S., et al.
Publicado: (2009)

Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay
por: Li, Jian, et al.
Publicado: (2006)

Structure-based virtual screening and biological evaluation of novel small-molecule BTK inhibitors
por: Lin, Tony Eight, et al.
Publicado: (2021)

Design, Synthesis and Evaluation of Novel Phorbazole C Derivatives as MNK Inhibitors through Virtual High-Throughput Screening
por: Jin, Xin, et al.
Publicado: (2022)

Crystal structure and Hirshfeld surface analysis of two (E)-N′-(para-substituted benzylidene) 4-chlorobenzenesulfonohydrazides
por: Salian, Akshatha R., et al.
Publicado: (2018)

Synthesis and Characterization of Novel Hydrazone Derivatives of Isonicotinic Hydrazide and Their Evaluation for Antibacterial and Cytotoxic Potential
por: Shah, Muhammad Abdullah, et al.
Publicado: (2022)

Synthesis and cytotoxic properties of novel (E)-3-benzylidene-7-methoxychroman-4-one derivatives
por: Noushini, Saeedeh, et al.
Publicado: (2013)

Novel Synthesis of Hydrazide-Hydrazone Derivatives and Their Utilization in the Synthesis of Coumarin, Pyridine, Thiazole and Thiophene Derivatives with Antitumor Activity
por: Mohareb, Rafat M., et al.
Publicado: (2010)

Crystal structure and Hirshfeld surface analysis of (E)-N′-benzylidene-4-chlorobenzenesulfonohydrazide and of its (E)-4-chloro-N′-(ortho- and para-methylbenzylidene)benzenesulfonohydrazide derivatives
por: Salian, Akshatha R., et al.
Publicado: (2018)

Benzyl 3-[(E)-benzylidene]dithiocarbazate
por: Shan, Shang, et al.
Publicado: (2008)

Isothiocyanatostilbenes as novel c-Met inhibitors
por: Gray, Alana L., et al.
Publicado: (2015)

Indene-Derived Hydrazides Targeting Acetylcholinesterase Enzyme in Alzheimer’s: Design, Synthesis, and Biological Evaluation
por: Gupta, Shraddha Manish, et al.
Publicado: (2022)

Virtual Screening, Synthesis and Biological Evaluation of Streptococcus mutans Mediated Biofilm Inhibitors
por: Atta, Lubna, et al.
Publicado: (2022)

Synthesis of Benzylidene Analogs of Oleanolic Acid as Potential α-Glucosidase and α-Amylase Inhibitors
por: Ke, Jun-Jie, et al.
Publicado: (2022)

Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis
por: Chen, Chang, et al.
Publicado: (2017)

Virtual Screening, Synthesis, and Biological Evaluation of Some Carbohydrazide Derivatives as Potential DPP-IV Inhibitors
por: Jadhav, Prerana B., et al.
Publicado: (2022)

Identification of MET fusions as novel therapeutic targets sensitive to MET inhibitors in lung cancer
por: Sun, Dantong, et al.
Publicado: (2023)

Hypoglycemic and Hypolipidemic Swords: Synthesis and In-vivo Biological Assessment of 5-benzylidene-2,4-thiazolidinediones
por: Patil, Vijay, et al.
Publicado: (2021)

Synthesis, Spectroscopic Analysis and Assessment of the Biological Activity of New Hydrazine and Hydrazide Derivatives of 3-Formylchromone
por: Słomiak, Krzysztof, et al.
Publicado: (2018)

Synthesis, Characterization, and Biologic Activity of New Acyl Hydrazides and 1,3,4-Oxadiazole Derivatives
por: Zarafu, Irina, et al.
Publicado: (2020)

Synthesis and Biological Evaluation of Dantrolene‐Like Hydrazide and Hydrazone Analogues as Multitarget Agents for Neurodegenerative Diseases
por: Bolognino, Isabella, et al.
Publicado: (2021)

Synthesis of novel 6,7-dimethoxy-4-anilinoquinolines as potent c-Met inhibitors
por: Zhang, Qing-Wen, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_o8vs9u17q10kuj20pros6j4d38