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The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following re...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968684/ https://www.ncbi.nlm.nih.gov/pubmed/31498409 http://dx.doi.org/10.1093/jnci/djz169 |
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author | Samet, Jonathan M Chiu, Weihsueh A Cogliano, Vincent Jinot, Jennifer Kriebel, David Lunn, Ruth M Beland, Frederick A Bero, Lisa Browne, Patience Fritschi, Lin Kanno, Jun Lachenmeier, Dirk W Lan, Qing Lasfargues, Gérard Le Curieux, Frank Peters, Susan Shubat, Pamela Sone, Hideko White, Mary C Williamson, Jon Yakubovskaya, Marianna Siemiatycki, Jack White, Paul A Guyton, Kathryn Z Schubauer-Berigan, Mary K Hall, Amy L Grosse, Yann Bouvard, Véronique Benbrahim-Tallaa, Lamia El Ghissassi, Fatiha Lauby-Secretan, Béatrice Armstrong, Bruce Saracci, Rodolfo Zavadil, Jiri Straif, Kurt Wild, Christopher P |
author_facet | Samet, Jonathan M Chiu, Weihsueh A Cogliano, Vincent Jinot, Jennifer Kriebel, David Lunn, Ruth M Beland, Frederick A Bero, Lisa Browne, Patience Fritschi, Lin Kanno, Jun Lachenmeier, Dirk W Lan, Qing Lasfargues, Gérard Le Curieux, Frank Peters, Susan Shubat, Pamela Sone, Hideko White, Mary C Williamson, Jon Yakubovskaya, Marianna Siemiatycki, Jack White, Paul A Guyton, Kathryn Z Schubauer-Berigan, Mary K Hall, Amy L Grosse, Yann Bouvard, Véronique Benbrahim-Tallaa, Lamia El Ghissassi, Fatiha Lauby-Secretan, Béatrice Armstrong, Bruce Saracci, Rodolfo Zavadil, Jiri Straif, Kurt Wild, Christopher P |
author_sort | Samet, Jonathan M |
collection | PubMed |
description | The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert advisory group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs program. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating, and integrating evidence to identify causes of human cancer. The advancements adopted include the strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals, and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. |
format | Online Article Text |
id | pubmed-6968684 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-69686842020-01-23 The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification Samet, Jonathan M Chiu, Weihsueh A Cogliano, Vincent Jinot, Jennifer Kriebel, David Lunn, Ruth M Beland, Frederick A Bero, Lisa Browne, Patience Fritschi, Lin Kanno, Jun Lachenmeier, Dirk W Lan, Qing Lasfargues, Gérard Le Curieux, Frank Peters, Susan Shubat, Pamela Sone, Hideko White, Mary C Williamson, Jon Yakubovskaya, Marianna Siemiatycki, Jack White, Paul A Guyton, Kathryn Z Schubauer-Berigan, Mary K Hall, Amy L Grosse, Yann Bouvard, Véronique Benbrahim-Tallaa, Lamia El Ghissassi, Fatiha Lauby-Secretan, Béatrice Armstrong, Bruce Saracci, Rodolfo Zavadil, Jiri Straif, Kurt Wild, Christopher P J Natl Cancer Inst Commentary The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert advisory group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs program. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating, and integrating evidence to identify causes of human cancer. The advancements adopted include the strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals, and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. Oxford University Press 2019-09-09 /pmc/articles/PMC6968684/ /pubmed/31498409 http://dx.doi.org/10.1093/jnci/djz169 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com. |
spellingShingle | Commentary Samet, Jonathan M Chiu, Weihsueh A Cogliano, Vincent Jinot, Jennifer Kriebel, David Lunn, Ruth M Beland, Frederick A Bero, Lisa Browne, Patience Fritschi, Lin Kanno, Jun Lachenmeier, Dirk W Lan, Qing Lasfargues, Gérard Le Curieux, Frank Peters, Susan Shubat, Pamela Sone, Hideko White, Mary C Williamson, Jon Yakubovskaya, Marianna Siemiatycki, Jack White, Paul A Guyton, Kathryn Z Schubauer-Berigan, Mary K Hall, Amy L Grosse, Yann Bouvard, Véronique Benbrahim-Tallaa, Lamia El Ghissassi, Fatiha Lauby-Secretan, Béatrice Armstrong, Bruce Saracci, Rodolfo Zavadil, Jiri Straif, Kurt Wild, Christopher P The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification |
title | The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification |
title_full | The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification |
title_fullStr | The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification |
title_full_unstemmed | The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification |
title_short | The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification |
title_sort | iarc monographs: updated procedures for modern and transparent evidence synthesis in cancer hazard identification |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968684/ https://www.ncbi.nlm.nih.gov/pubmed/31498409 http://dx.doi.org/10.1093/jnci/djz169 |
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