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The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification

The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following re...

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Autores principales: Samet, Jonathan M, Chiu, Weihsueh A, Cogliano, Vincent, Jinot, Jennifer, Kriebel, David, Lunn, Ruth M, Beland, Frederick A, Bero, Lisa, Browne, Patience, Fritschi, Lin, Kanno, Jun, Lachenmeier, Dirk W, Lan, Qing, Lasfargues, Gérard, Le Curieux, Frank, Peters, Susan, Shubat, Pamela, Sone, Hideko, White, Mary C, Williamson, Jon, Yakubovskaya, Marianna, Siemiatycki, Jack, White, Paul A, Guyton, Kathryn Z, Schubauer-Berigan, Mary K, Hall, Amy L, Grosse, Yann, Bouvard, Véronique, Benbrahim-Tallaa, Lamia, El Ghissassi, Fatiha, Lauby-Secretan, Béatrice, Armstrong, Bruce, Saracci, Rodolfo, Zavadil, Jiri, Straif, Kurt, Wild, Christopher P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968684/
https://www.ncbi.nlm.nih.gov/pubmed/31498409
http://dx.doi.org/10.1093/jnci/djz169
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author Samet, Jonathan M
Chiu, Weihsueh A
Cogliano, Vincent
Jinot, Jennifer
Kriebel, David
Lunn, Ruth M
Beland, Frederick A
Bero, Lisa
Browne, Patience
Fritschi, Lin
Kanno, Jun
Lachenmeier, Dirk W
Lan, Qing
Lasfargues, Gérard
Le Curieux, Frank
Peters, Susan
Shubat, Pamela
Sone, Hideko
White, Mary C
Williamson, Jon
Yakubovskaya, Marianna
Siemiatycki, Jack
White, Paul A
Guyton, Kathryn Z
Schubauer-Berigan, Mary K
Hall, Amy L
Grosse, Yann
Bouvard, Véronique
Benbrahim-Tallaa, Lamia
El Ghissassi, Fatiha
Lauby-Secretan, Béatrice
Armstrong, Bruce
Saracci, Rodolfo
Zavadil, Jiri
Straif, Kurt
Wild, Christopher P
author_facet Samet, Jonathan M
Chiu, Weihsueh A
Cogliano, Vincent
Jinot, Jennifer
Kriebel, David
Lunn, Ruth M
Beland, Frederick A
Bero, Lisa
Browne, Patience
Fritschi, Lin
Kanno, Jun
Lachenmeier, Dirk W
Lan, Qing
Lasfargues, Gérard
Le Curieux, Frank
Peters, Susan
Shubat, Pamela
Sone, Hideko
White, Mary C
Williamson, Jon
Yakubovskaya, Marianna
Siemiatycki, Jack
White, Paul A
Guyton, Kathryn Z
Schubauer-Berigan, Mary K
Hall, Amy L
Grosse, Yann
Bouvard, Véronique
Benbrahim-Tallaa, Lamia
El Ghissassi, Fatiha
Lauby-Secretan, Béatrice
Armstrong, Bruce
Saracci, Rodolfo
Zavadil, Jiri
Straif, Kurt
Wild, Christopher P
author_sort Samet, Jonathan M
collection PubMed
description The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert advisory group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs program. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating, and integrating evidence to identify causes of human cancer. The advancements adopted include the strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals, and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention.
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spelling pubmed-69686842020-01-23 The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification Samet, Jonathan M Chiu, Weihsueh A Cogliano, Vincent Jinot, Jennifer Kriebel, David Lunn, Ruth M Beland, Frederick A Bero, Lisa Browne, Patience Fritschi, Lin Kanno, Jun Lachenmeier, Dirk W Lan, Qing Lasfargues, Gérard Le Curieux, Frank Peters, Susan Shubat, Pamela Sone, Hideko White, Mary C Williamson, Jon Yakubovskaya, Marianna Siemiatycki, Jack White, Paul A Guyton, Kathryn Z Schubauer-Berigan, Mary K Hall, Amy L Grosse, Yann Bouvard, Véronique Benbrahim-Tallaa, Lamia El Ghissassi, Fatiha Lauby-Secretan, Béatrice Armstrong, Bruce Saracci, Rodolfo Zavadil, Jiri Straif, Kurt Wild, Christopher P J Natl Cancer Inst Commentary The Monographs produced by the International Agency for Research on Cancer (IARC) apply rigorous procedures for the scientific review and evaluation of carcinogenic hazards by independent experts. The Preamble to the IARC Monographs, which outlines these procedures, was updated in 2019, following recommendations of a 2018 expert advisory group. This article presents the key features of the updated Preamble, a major milestone that will enable IARC to take advantage of recent scientific and procedural advances made during the 12 years since the last Preamble amendments. The updated Preamble formalizes important developments already being pioneered in the Monographs program. These developments were taken forward in a clarified and strengthened process for identifying, reviewing, evaluating, and integrating evidence to identify causes of human cancer. The advancements adopted include the strengthening of systematic review methodologies; greater emphasis on mechanistic evidence, based on key characteristics of carcinogens; greater consideration of quality and informativeness in the critical evaluation of epidemiological studies, including their exposure assessment methods; improved harmonization of evaluation criteria for the different evidence streams; and a single-step process of integrating evidence on cancer in humans, cancer in experimental animals, and mechanisms for reaching overall evaluations. In all, the updated Preamble underpins a stronger and more transparent method for the identification of carcinogenic hazards, the essential first step in cancer prevention. Oxford University Press 2019-09-09 /pmc/articles/PMC6968684/ /pubmed/31498409 http://dx.doi.org/10.1093/jnci/djz169 Text en © The Author(s) 2019. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contactjournals.permissions@oup.com.
spellingShingle Commentary
Samet, Jonathan M
Chiu, Weihsueh A
Cogliano, Vincent
Jinot, Jennifer
Kriebel, David
Lunn, Ruth M
Beland, Frederick A
Bero, Lisa
Browne, Patience
Fritschi, Lin
Kanno, Jun
Lachenmeier, Dirk W
Lan, Qing
Lasfargues, Gérard
Le Curieux, Frank
Peters, Susan
Shubat, Pamela
Sone, Hideko
White, Mary C
Williamson, Jon
Yakubovskaya, Marianna
Siemiatycki, Jack
White, Paul A
Guyton, Kathryn Z
Schubauer-Berigan, Mary K
Hall, Amy L
Grosse, Yann
Bouvard, Véronique
Benbrahim-Tallaa, Lamia
El Ghissassi, Fatiha
Lauby-Secretan, Béatrice
Armstrong, Bruce
Saracci, Rodolfo
Zavadil, Jiri
Straif, Kurt
Wild, Christopher P
The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
title The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
title_full The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
title_fullStr The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
title_full_unstemmed The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
title_short The IARC Monographs: Updated Procedures for Modern and Transparent Evidence Synthesis in Cancer Hazard Identification
title_sort iarc monographs: updated procedures for modern and transparent evidence synthesis in cancer hazard identification
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968684/
https://www.ncbi.nlm.nih.gov/pubmed/31498409
http://dx.doi.org/10.1093/jnci/djz169
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