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A Review of the Role of Carcinoembryonic Antigen in Clinical Practice

Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in...

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Autores principales: Hall, Claire, Clarke, Louise, Pal, Atanu, Buchwald, Pamela, Eglinton, Tim, Wakeman, Chris, Frizelle, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Coloproctology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968721/
https://www.ncbi.nlm.nih.gov/pubmed/31937069
http://dx.doi.org/10.3393/ac.2019.11.13
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author Hall, Claire
Clarke, Louise
Pal, Atanu
Buchwald, Pamela
Eglinton, Tim
Wakeman, Chris
Frizelle, Frank
author_facet Hall, Claire
Clarke, Louise
Pal, Atanu
Buchwald, Pamela
Eglinton, Tim
Wakeman, Chris
Frizelle, Frank
author_sort Hall, Claire
collection PubMed
description Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer.
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spelling pubmed-69687212020-01-24 A Review of the Role of Carcinoembryonic Antigen in Clinical Practice Hall, Claire Clarke, Louise Pal, Atanu Buchwald, Pamela Eglinton, Tim Wakeman, Chris Frizelle, Frank Ann Coloproctol Review Carcinoembryonic antigen (CEA) is not normally produced in significant quantities after birth but is elevated in colorectal cancer. The aim of this review was to define the current role of CEA and how best to investigate patients with elevated CEA levels. A systematic review of CEA was performed, in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Studies were identified from PubMed, Cochrane library, and controlled trials registers. We identified 2,712 papers of which 34 were relevant. Analysis of these papers found higher preoperative CEA levels were associated with advanced or metastatic disease and thus poorer prognosis. Postoperatively, failure of CEA to return to normal was found to be indicative of residual or recurrent disease. However, measurement of CEA levels alone was not sufficient to improve survival rates. Two algorithms are proposed to guide investigation of patients with elevated CEA: one for patients with elevated CEA after CRC resection, and another for patients with de novo elevated CEA. CEA measurement has an important role in the investigation, management and follow-up of patients with colorectal cancer. Korean Society of Coloproctology 2019-12 2019-12-31 /pmc/articles/PMC6968721/ /pubmed/31937069 http://dx.doi.org/10.3393/ac.2019.11.13 Text en © 2019 The Korean Society of Coloproctology This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Hall, Claire
Clarke, Louise
Pal, Atanu
Buchwald, Pamela
Eglinton, Tim
Wakeman, Chris
Frizelle, Frank
A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
title A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
title_full A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
title_fullStr A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
title_full_unstemmed A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
title_short A Review of the Role of Carcinoembryonic Antigen in Clinical Practice
title_sort review of the role of carcinoembryonic antigen in clinical practice
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968721/
https://www.ncbi.nlm.nih.gov/pubmed/31937069
http://dx.doi.org/10.3393/ac.2019.11.13
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