Knock-in of Mutated hTAU Causes Insulin Resistance, Inflammation and Proteostasis Disturbance in a Mouse Model of Frontotemporal Dementia

Diabetes and obesity have been implicated as risk factors for dementia. However, metabolic mechanisms and associated signalling pathways have not been investigated in detail in frontotemporal dementia. We therefore here characterised physiological, behavioural and molecular phenotypes of 3- and 8-mo...

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Detalles Bibliográficos
Autores principales: Hull, Claire, Dekeryte, Ruta, Koss, David J., Crouch, Barry, Buchanan, Heather, Delibegovic, Mirela, Platt, Bettina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968995/
https://www.ncbi.nlm.nih.gov/pubmed/31396860
http://dx.doi.org/10.1007/s12035-019-01722-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6968995/
https://www.ncbi.nlm.nih.gov/pubmed/31396860
http://dx.doi.org/10.1007/s12035-019-01722-6

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