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Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform

Precise control of hepatic glucose production (HGP) is pivotal to maintain systemic glucose homeostasis. HNF4α functions to stimulate transcription of key gluconeogenic genes. HNF4α harbors two promoters (P2 and P1) thought to be primarily active in fetal and adult livers, respectively. Here we repo...

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Detalles Bibliográficos
Autores principales:	Da Li, Cao, Tiefeng, Sun, Xiaoli, Jin, Sungho, Di Xie, Huang, Xinmei, Yang, Xiaoyong, Carmichael, Gordon G., Taylor, Hugh S., Diano, Sabrina, Huang, Yingqun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969024/ https://www.ncbi.nlm.nih.gov/pubmed/31953394 http://dx.doi.org/10.1038/s41467-019-14185-z

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