Accelerated neuronal and synaptic maturation by BrainPhys medium increases Aβ secretion and alters Aβ peptide ratios from iPSC-derived cortical neurons

One of the neuropathological hallmarks of Alzheimer’s disease (AD) is cerebral deposition of amyloid plaques composed of amyloid β (Aβ) peptides and the cerebrospinal fluid concentrations of those peptides are used as a biomarker for AD. Mature induced pluripotent stem cell (iPSC)-derived cortical n...

Descripción completa

Detalles Bibliográficos
Autores principales: Satir, Tugce Munise, Nazir, Faisal Hayat, Vizlin-Hodzic, Dzeneta, Hardselius, Erik, Blennow, Kaj, Wray, Selina, Zetterberg, Henrik, Agholme, Lotta, Bergström, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969066/
https://www.ncbi.nlm.nih.gov/pubmed/31953468
http://dx.doi.org/10.1038/s41598-020-57516-7

Ejemplares similares

Ejemplares similares