MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

Neuroendocrine prostate cancer (NEPC) is an aggressive malignancy with no effective targeted therapies. The oncogenic MUC1-C protein is overexpressed in castration-resistant prostate cancer (CRPC) and NEPC, but its specific role is unknown. Here, we demonstrate that upregulation of MUC1-C in androge...

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Detalles Bibliográficos
Autores principales: Yasumizu, Yota, Rajabi, Hasan, Jin, Caining, Hata, Tsuyoshi, Pitroda, Sean, Long, Mark D., Hagiwara, Masayuki, Li, Wei, Hu, Qiang, Liu, Song, Yamashita, Nami, Fushimi, Atsushi, Kui, Ling, Samur, Mehmet, Yamamoto, Masaaki, Zhang, Yan, Zhang, Ning, Hong, Deli, Maeda, Takahiro, Kosaka, Takeo, Wong, Kwok K., Oya, Mototsugu, Kufe, Donald
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969104/
https://www.ncbi.nlm.nih.gov/pubmed/31953400
http://dx.doi.org/10.1038/s41467-019-14219-6

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