Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder characterized by the presence of intracellular aggregates of tau protein and neuronal loss leading to cognitive and motor impairment. Occurrence is mostly sporadic, but rare family clusters have been described. Although the etiopat...

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Detalles Bibliográficos
Autores principales: Alquezar, Carolina, Felix, Jessica B., McCandlish, Elizabeth, Buckley, Brian T., Caparros-Lefebvre, Dominique, Karch, Celeste M., Golbe, Lawrence I., Kao, Aimee W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969162/
https://www.ncbi.nlm.nih.gov/pubmed/31953414
http://dx.doi.org/10.1038/s41598-019-56930-w

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