Cargando…

Design and Molecular dynamic Investigations of 7,8-Dihydroxyflavone Derivatives as Potential Neuroprotective Agents Against Alpha-synuclein

Parkinson’s disease (PD) is the second most common neurodegenerative disorder caused due to loss of dopaminergic neurons in substantia nigra pars compacta, which occurs the presence of Lewy bodies made up of Alpha-synuclein (ASN) aggregation resulting in neuronal death. This study aims to identify p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thangavel, Mohankumar, Chandramohan, Vivek, Shankaraiah, Lalithamba Haralur, Jayaraj, Richard L., Poomani, Kumaradhas, Magudeeswaran, Sivanandam, Govindasamy, Hunday, Vijayakumar, Rajendran, Rangasamy, Balakrishnan, Dharmar, Manimaran, Namasivayam, Elangovan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969171/ https://www.ncbi.nlm.nih.gov/pubmed/31953434 http://dx.doi.org/10.1038/s41598-020-57417-9

Ejemplares similares

Author Correction: Design and Molecular dynamic Investigations of 7,8-Dihydroxyflavone Derivatives as Potential Neuroprotective Agents Against Alpha-synuclein
por: Mohankumar, Thangavel, et al.
Publicado: (2020)

Binding mechanism of naringenin with monoamine oxidase – B enzyme: QM/MM and molecular dynamics perspective
por: Govindasamy, Hunday, et al.
Publicado: (2021)

Strong Binding of Leupeptin with TMPRSS2 Protease May Be an Alternative to Camostat and Nafamostat for SARS-CoV-2 Repurposed Drug: Evaluation from Molecular Docking and Molecular Dynamics Simulations
por: Ramakrishnan, Jaganathan, et al.
Publicado: (2021)

7,8-Dihydroxyflavone Enhances Cue-Conditioned Alcohol Reinstatement in Rats
por: Hogarth, Samuel J., et al.
Publicado: (2020)

Synapse‐selective rapid potentiation of hippocampal synaptic transmission by 7,8‐dihydroxyflavone
por: Kobayashi, Katsunori, et al.
Publicado: (2018)

Baicalein, 7,8-Dihydroxyflavone and Myricetin as Potent Inhibitors of Human Ornithine Decarboxylase
por: Liu, Yun-Chin, et al.
Publicado: (2020)

The TrkB agonist, 7,8-dihydroxyflavone, impairs fracture healing in mice
por: Johnstone, Maddison R., et al.
Publicado: (2021)

7,8-Dihydroxyflavone modulates bone formation and resorption and ameliorates ovariectomy-induced osteoporosis
por: Xue, Fan, et al.
Publicado: (2021)

Metabolic protection by the dietary flavonoid 7,8-dihydroxyflavone requires an intact gut microbiome
por: Sharma, Priyanka, et al.
Publicado: (2022)

Rescue of Long-Term Spatial Memory by 7,8-Dihydroxyflavone in Mice with Reduced Oligodendrogenesis
por: Rawlings-Mortimer, Florence, et al.
Publicado: (2023)

Effect of 7,8-Dihydroxyflavone as an Antioxidant on In Vitro Maturation of Oocytes and Development of Parthenogenetic Embryos in Pigs
por: CHOI, Ji-Yei, et al.
Publicado: (2013)

7,8-Dihydroxyflavone Protects Nigrostriatal Dopaminergic Neurons from Rotenone-Induced Neurotoxicity in Rodents
por: Nie, Shuke, et al.
Publicado: (2019)

7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress
por: Cho, Suk Ju, et al.
Publicado: (2019)

Low-dose 7,8-Dihydroxyflavone Administration After Status Epilepticus Prevents Epilepsy Development
por: Guarino, Annunziata, et al.
Publicado: (2022)

7,8-Dihydroxyflavone and Neuropsychiatric Disorders: A Translational Perspective from the Mechanism to Drug Development
por: Yang, Shaojie, et al.
Publicado: (2022)

Crystal structure and Hirshfeld surface analysis of 4-aminopyridinium thiocyanate–4-aminopyridine (1/1)
por: Renugadevi, M., et al.
Publicado: (2020)

Exploring the Molecular Interactions of 7,8-Dihydroxyflavone and Its Derivatives with TrkB and VEGFR2 Proteins
por: Chitranshi, Nitin, et al.
Publicado: (2015)

7,8-Dihydroxyflavone activates Nrf2/HO-1 signaling pathways and protects against osteoarthritis
por: Cai, Dawei, et al.
Publicado: (2019)

Sex-Dependent Effects of 7,8-Dihydroxyflavone on Metabolic Health Are Associated with Alterations in the Host Gut Microbiome
por: Sharma, Priyanka, et al.
Publicado: (2021)

7,8-dihydroxyflavone enhances long-term spatial memory and alters brain volume in wildtype mice
por: Rawlings-Mortimer, Florence, et al.
Publicado: (2023)

3D printed elastic hydrogel conduits with 7,8-dihydroxyflavone release for peripheral nerve repair
por: Wu, Wenbi, et al.
Publicado: (2023)

7,8-Dihydroxyflavone Ameliorates Cognitive Impairment by Inhibiting Expression of Tau Pathology in ApoE-Knockout Mice
por: Tan, Yang, et al.
Publicado: (2016)

7,8-Dihydroxyflavone Attenuates Inflammatory Response and Insulin Resistance Induced by the Paracrine Interaction between Adipocytes and Macrophages
por: Shin, Ye-Eun, et al.
Publicado: (2023)

Impact of dietary plant flavonoids on 7,8‐dihydroxyflavone transepithelial transport in human intestinal Caco‐2 cells
por: Chen, Yufeng, et al.
Publicado: (2023)

7,8-dihydroxyflavone ameliorates motor deficits via regulating autophagy in MPTP-induced mouse model of Parkinson’s disease
por: Zuo, Li, et al.
Publicado: (2021)

Establishment and Characterization of Stable Zein/Glycosylated Lactoferrin Nanoparticles to Enhance the Storage Stability and in vitro Bioaccessibility of 7,8-Dihydroxyflavone
por: Chen, Yufeng, et al.
Publicado: (2022)

7,8-Dihydroxyflavone induces mitochondrial apoptosis and down-regulates the expression of ganglioside GD3 in malignant melanoma cells
por: Ju, Won Seok, et al.
Publicado: (2023)

7,8-dihydroxyflavone, a small molecular TrkB agonist, is useful for treating various BDNF-implicated human disorders
por: Liu, Chaoyang, et al.
Publicado: (2016)

Effects of 7,8-Dihydroxyflavone on Lipid Isoprenoid and Rho Protein Levels in Brains of Aged C57BL/6 Mice
por: Ötzkan, Sarah, et al.
Publicado: (2020)

7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder
por: Bryant, Joseph, et al.
Publicado: (2021)

7,8-Dihydroxyflavone protects neurons against oxygen-glucose deprivation induced apoptosis and activates the TrkB/Akt pathway
por: Zhou, Qinxiang, et al.
Publicado: (2022)

Correction: 7,8-Dihydroxyflavone induces mitochondrial apoptosis and down-regulates the expression of ganglioside GD3 in malignant melanoma cells
por: Ju, Won Seok, et al.
Publicado: (2023)

Isolongifolene-loaded chitosan nanoparticles synthesis and characterization for cancer treatment
por: Manimaran, Dharmar, et al.
Publicado: (2022)

Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone
por: Han, Mei, et al.
Publicado: (2017)

Intake of 7,8-Dihydroxyflavone During Juvenile and Adolescent Stages Prevents Onset of Psychosis in Adult Offspring After Maternal Immune Activation
por: Han, Mei, et al.
Publicado: (2016)

7,8-Dihydroxyflavone Attenuates Alcohol-Related Behavior in Rat Models of Alcohol Consumption via TrkB in the Ventral Tegmental Area
por: Li, Xin-Xin, et al.
Publicado: (2020)

Author Correction: 7,8-Dihydroxyflavone improves neuropathological changes in the brain of Tg26 mice, a model for HIV-associated neurocognitive disorder
por: Bryant, Joseph, et al.
Publicado: (2021)

Impaired Brain Mitochondrial Bioenergetics in the Ts65Dn Mouse Model of Down Syndrome Is Restored by Neonatal Treatment with the Polyphenol 7,8-Dihydroxyflavone
por: Valenti, Daniela, et al.
Publicado: (2021)

7,8-Dihydroxyflavone Suppresses Oxidative Stress-Induced Base Modification in DNA via Induction of the Repair Enzyme 8-Oxoguanine DNA Glycosylase-1
por: Kim, Ki Cheon, et al.
Publicado: (2013)

Crosstalk between the muscular estrogen receptor α and BDNF/TrkB signaling alleviates metabolic syndrome via 7,8-dihydroxyflavone in female mice
por: Zhao, Zhenlei, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lk3snvudm250ft8qg79sr6rr95