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Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial

In a nationwide randomized controlled trial, white matter microstructure was assessed before and immediately after Cogmed Working-Memory Training (CWMT) in school-age neonatal critical illness survivors. Eligible participants were survivors (8–12 years) with an IQ ≥ 80 and a z-score of ≤ −1.5 on (wo...

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Autores principales: Schiller, Raisa M., IJsselstijn, Hanneke, Madderom, Marlous J., van Rosmalen, Joost, van Heijst, Arno F.J., Smits, Marion, Verhulst, Frank, Tibboel, Dick, White, Tonya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969347/
https://www.ncbi.nlm.nih.gov/pubmed/31299479
http://dx.doi.org/10.1016/j.dcn.2019.100678
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author Schiller, Raisa M.
IJsselstijn, Hanneke
Madderom, Marlous J.
van Rosmalen, Joost
van Heijst, Arno F.J.
Smits, Marion
Verhulst, Frank
Tibboel, Dick
White, Tonya
author_facet Schiller, Raisa M.
IJsselstijn, Hanneke
Madderom, Marlous J.
van Rosmalen, Joost
van Heijst, Arno F.J.
Smits, Marion
Verhulst, Frank
Tibboel, Dick
White, Tonya
author_sort Schiller, Raisa M.
collection PubMed
description In a nationwide randomized controlled trial, white matter microstructure was assessed before and immediately after Cogmed Working-Memory Training (CWMT) in school-age neonatal critical illness survivors. Eligible participants were survivors (8–12 years) with an IQ ≥ 80 and a z-score of ≤ −1.5 on (working)memory test at first assessment. Diffusion Tensor Imaging was used to assess white matter microstructure. Associations between any training-induced changes and improved neuropsychological outcome immediately and one year post-CWMT were evaluated as well. The trial was conducted between October 2014–June 2017 at Erasmus MC-Sophia, Rotterdam, Netherlands. Researchers involved were blinded to group allocation. Participants were randomized to CWMT(n = 14) or no-intervention(n = 20). All children completed the CWMT. Global fractional anisotropy(FA) increased significantly post-CWMT compared to no-intervention(estimated-coefficient = .007, p = .015). Increased FA(estimated coefficient = .009, p = .033) and decreased mean diffusivity(estimated-coefficient = −.010, p = .018) were found in the left superior longitudinal fasciculus(SFL) post-CWMT compared no-intervention. Children after CWMT who improved with >1SD on verbal working-memory had significantly higher FA in the left SLF post-CWMT(n = 6; improvement = .408 ± .01) than children without this improvement post-CWMT(n = 6; no-improvement = .384 ± .02), F(1,12) = 6.22, p = .041, [Formula: see text]  = .47. No other structure-function relationships were found post-CWMT. Our findings demonstrate that white matter microstructure and associated cognitive outcomes are malleable by CWMT in survivors of neonatal critical illness.
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spelling pubmed-69693472020-01-21 Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial Schiller, Raisa M. IJsselstijn, Hanneke Madderom, Marlous J. van Rosmalen, Joost van Heijst, Arno F.J. Smits, Marion Verhulst, Frank Tibboel, Dick White, Tonya Dev Cogn Neurosci Original Research In a nationwide randomized controlled trial, white matter microstructure was assessed before and immediately after Cogmed Working-Memory Training (CWMT) in school-age neonatal critical illness survivors. Eligible participants were survivors (8–12 years) with an IQ ≥ 80 and a z-score of ≤ −1.5 on (working)memory test at first assessment. Diffusion Tensor Imaging was used to assess white matter microstructure. Associations between any training-induced changes and improved neuropsychological outcome immediately and one year post-CWMT were evaluated as well. The trial was conducted between October 2014–June 2017 at Erasmus MC-Sophia, Rotterdam, Netherlands. Researchers involved were blinded to group allocation. Participants were randomized to CWMT(n = 14) or no-intervention(n = 20). All children completed the CWMT. Global fractional anisotropy(FA) increased significantly post-CWMT compared to no-intervention(estimated-coefficient = .007, p = .015). Increased FA(estimated coefficient = .009, p = .033) and decreased mean diffusivity(estimated-coefficient = −.010, p = .018) were found in the left superior longitudinal fasciculus(SFL) post-CWMT compared no-intervention. Children after CWMT who improved with >1SD on verbal working-memory had significantly higher FA in the left SLF post-CWMT(n = 6; improvement = .408 ± .01) than children without this improvement post-CWMT(n = 6; no-improvement = .384 ± .02), F(1,12) = 6.22, p = .041, [Formula: see text]  = .47. No other structure-function relationships were found post-CWMT. Our findings demonstrate that white matter microstructure and associated cognitive outcomes are malleable by CWMT in survivors of neonatal critical illness. Elsevier 2019-06-27 /pmc/articles/PMC6969347/ /pubmed/31299479 http://dx.doi.org/10.1016/j.dcn.2019.100678 Text en © 2019 Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Original Research
Schiller, Raisa M.
IJsselstijn, Hanneke
Madderom, Marlous J.
van Rosmalen, Joost
van Heijst, Arno F.J.
Smits, Marion
Verhulst, Frank
Tibboel, Dick
White, Tonya
Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial
title Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial
title_full Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial
title_fullStr Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial
title_full_unstemmed Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial
title_short Training-induced white matter microstructure changes in survivors of neonatal critical illness: A randomized controlled trial
title_sort training-induced white matter microstructure changes in survivors of neonatal critical illness: a randomized controlled trial
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969347/
https://www.ncbi.nlm.nih.gov/pubmed/31299479
http://dx.doi.org/10.1016/j.dcn.2019.100678
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