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DNA–dependent protein kinase in telomere maintenance and protection

This review focuses on DNA–dependent protein kinase (DNA–PK), which is the key regulator of canonical non–homologous end–joining (NHEJ), the predominant mechanism of DNA double–strand break (DSB) repair in mammals. DNA–PK consists of the DNA–binding Ku70/80 heterodimer and the catalytic subunit DNA–...

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Detalles Bibliográficos
Autores principales:	Sui, Jiangdong, Zhang, Shichuan, Chen, Benjamin P. C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Review Letter
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969447/ https://www.ncbi.nlm.nih.gov/pubmed/31988640 http://dx.doi.org/10.1186/s11658-020-0199-0

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