Povidone-iodine pharmacokinetics and study design

Dr. Gnanasekaran et al. reported the bactericidal activity of various concentrations of povidone iodine (PI) solution in an agar plate experiment of respiratory flora. The study design and the pharmacokinetic properties of PI solution ensured that dilute PI would not be effective in this study. Thes...

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Autores principales: Koerner, Jagger, Grzybowski, Andrzej
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Correspondence
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969449/
https://www.ncbi.nlm.nih.gov/pubmed/31952486
http://dx.doi.org/10.1186/s12886-020-1313-9
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author Koerner, Jagger
Grzybowski, Andrzej
author_facet Koerner, Jagger
Grzybowski, Andrzej
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description Dr. Gnanasekaran et al. reported the bactericidal activity of various concentrations of povidone iodine (PI) solution in an agar plate experiment of respiratory flora. The study design and the pharmacokinetic properties of PI solution ensured that dilute PI would not be effective in this study. These results may not replicate the typical clinical situation and are significantly different than a previously reported agar plate experiment, again owing to subtle but very significant differences in methodology.
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spelling pubmed-69694492020-01-27 Povidone-iodine pharmacokinetics and study design Koerner, Jagger Grzybowski, Andrzej BMC Ophthalmol Correspondence Dr. Gnanasekaran et al. reported the bactericidal activity of various concentrations of povidone iodine (PI) solution in an agar plate experiment of respiratory flora. The study design and the pharmacokinetic properties of PI solution ensured that dilute PI would not be effective in this study. These results may not replicate the typical clinical situation and are significantly different than a previously reported agar plate experiment, again owing to subtle but very significant differences in methodology. BioMed Central 2020-01-17 /pmc/articles/PMC6969449/ /pubmed/31952486 http://dx.doi.org/10.1186/s12886-020-1313-9 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Correspondence
Koerner, Jagger
Grzybowski, Andrzej
Povidone-iodine pharmacokinetics and study design
title Povidone-iodine pharmacokinetics and study design
title_full Povidone-iodine pharmacokinetics and study design
title_fullStr Povidone-iodine pharmacokinetics and study design
title_full_unstemmed Povidone-iodine pharmacokinetics and study design
title_short Povidone-iodine pharmacokinetics and study design
title_sort povidone-iodine pharmacokinetics and study design
topic Correspondence
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969449/
https://www.ncbi.nlm.nih.gov/pubmed/31952486
http://dx.doi.org/10.1186/s12886-020-1313-9
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