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Pre-treatment with the viral Toll-like receptor 3 agonist poly(I:C) modulates innate immunity and protects neutropenic mice infected intracerebrally with Escherichia coli

BACKGROUND: Individuals with impaired immunity are more susceptible to infections than immunocompetent subjects. No vaccines are currently available to induce protection against E. coli meningoencephalitis. This study evaluated the potential of poly(I:C) pre-treatment to induce trained immunity. Pol...

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Detalles Bibliográficos
Autores principales:	Ribes, Sandra, Arcilla, Christa, Ott, Martina, Schütze, Sandra, Hanisch, Uwe-Karsten, Nessler, Stefan, Nau, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969464/ https://www.ncbi.nlm.nih.gov/pubmed/31952519 http://dx.doi.org/10.1186/s12974-020-1700-4

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