Revisiting the tumorigenesis timeline with a data-driven generative model

Cancer is driven by the sequential accumulation of genetic and epigenetic changes in oncogenes and tumor suppressor genes. The timing of these events is not well understood. Moreover, it is currently unknown why the same driver gene change appears as an early event in some cancer types and as a late...

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Detalles Bibliográficos
Autores principales: Lahouel, Kamel, Younes, Laurent, Danilova, Ludmila, Giardiello, Francis M., Hruban, Ralph H., Groopman, John, Kinzler, Kenneth W., Vogelstein, Bert, Geman, Donald, Tomasetti, Cristian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Physical Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969520/
https://www.ncbi.nlm.nih.gov/pubmed/31882448
http://dx.doi.org/10.1073/pnas.1914589117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969520/
https://www.ncbi.nlm.nih.gov/pubmed/31882448
http://dx.doi.org/10.1073/pnas.1914589117

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