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Revisiting the tumorigenesis timeline with a data-driven generative model
Cancer is driven by the sequential accumulation of genetic and epigenetic changes in oncogenes and tumor suppressor genes. The timing of these events is not well understood. Moreover, it is currently unknown why the same driver gene change appears as an early event in some cancer types and as a late...
Autores principales: | Lahouel, Kamel, Younes, Laurent, Danilova, Ludmila, Giardiello, Francis M., Hruban, Ralph H., Groopman, John, Kinzler, Kenneth W., Vogelstein, Bert, Geman, Donald, Tomasetti, Cristian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969520/ https://www.ncbi.nlm.nih.gov/pubmed/31882448 http://dx.doi.org/10.1073/pnas.1914589117 |
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