Cargando…
A general-purpose protein design framework based on mining sequence–structure relationships in known protein structures
Current state-of-the-art approaches to computational protein design (CPD) aim to capture the determinants of structure from physical principles. While this has led to many successful designs, it does have strong limitations associated with inaccuracies in physical modeling, such that a reliable gene...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2020
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969538/ https://www.ncbi.nlm.nih.gov/pubmed/31892539 http://dx.doi.org/10.1073/pnas.1908723117 |