Intratumoral injection of the seasonal flu shot converts immunologically cold tumors to hot and serves as an immunotherapy for cancer

Reprogramming the tumor microenvironment to increase immune-mediated responses is currently of intense interest. Patients with immune-infiltrated “hot” tumors demonstrate higher treatment response rates and improved survival. However, only the minority of tumors are hot, and a limited proportion of...

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Detalles Bibliográficos
Autores principales: Newman, Jenna H., Chesson, C. Brent, Herzog, Nora L., Bommareddy, Praveen K., Aspromonte, Salvatore M., Pepe, Russell, Estupinian, Ricardo, Aboelatta, Mones M., Buddhadev, Stuti, Tarabichi, Saeed, Lee, Michael, Li, Shengguo, Medina, Daniel J., Giurini, Eileena F., Gupta, Kajal H., Guevara-Aleman, Gabriel, Rossi, Marco, Nowicki, Christina, Abed, Abdulkareem, Goldufsky, Josef W., Broucek, Joseph R., Redondo, Raquel E., Rotter, David, Jhawar, Sachin R., Wang, Shang-Jui, Kohlhapp, Frederick J., Kaufman, Howard L., Thomas, Paul G., Gupta, Vineet, Kuzel, Timothy M., Reiser, Jochen, Paras, Joyce, Kane, Michael P., Singer, Eric A., Malhotra, Jyoti, Denzin, Lisa K., Sant’Angelo, Derek B., Rabson, Arnold B., Lee, Leonard Y., Lasfar, Ahmed, Langenfeld, John, Schenkel, Jason M., Fidler, Mary Jo, Ruiz, Emily S., Marzo, Amanda L., Rudra, Jai S., Silk, Ann W., Zloza, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969546/
https://www.ncbi.nlm.nih.gov/pubmed/31888983
http://dx.doi.org/10.1073/pnas.1904022116

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