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Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism
Ocular accommodation is not just a mechanism for altering curvature of the crystalline lens of the eye, it also enables aqueous humor outflow through the trabecular meshwork, influencing intraocular pressure (IOP). Long term stress on the ciliary muscle from sustained near focusing may initiate myop...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Medical Hypothesis, Discovery & Innovation Ophthalmology
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969557/ https://www.ncbi.nlm.nih.gov/pubmed/31976346 |
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author | Aggarwala, Karan R Gregg |
author_facet | Aggarwala, Karan R Gregg |
author_sort | Aggarwala, Karan R Gregg |
collection | PubMed |
description | Ocular accommodation is not just a mechanism for altering curvature of the crystalline lens of the eye, it also enables aqueous humor outflow through the trabecular meshwork, influencing intraocular pressure (IOP). Long term stress on the ciliary muscle from sustained near focusing may initiate myopic eye growth in children and primary open angle glaucoma in presbyopic adults. Multi-factorial studies of ocular accommodation that include measures of IOP, ciliary muscle morphology, anterior chamber depth and assessment of nutritional intake and metabolic markers may elucidate etiology and novel strategies for management of both myopia and chronic glaucoma. Anatomy of the ciliary fibers from anterior insertion in the fluid drainage pathway to their posterior consanguinity with the vascular choroid, alters ocular parameters such as micro-fluctuations of accommodation and pulsatile ocular blood flow that are driven by cardiac contractions conveyed by carotid arteries. Stretching of the choroid has consequences for thinning of the peripheral retina, sclera and lamina cribrosa with potential to induce retinal tears and optic nerve cupping. Early metabolic interventions may lead to prevention or reduced severity of myopia and glaucoma. Finally, it might improve quality of life of patients and decrease disability from visual impairment and blindness. |
format | Online Article Text |
id | pubmed-6969557 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Medical Hypothesis, Discovery & Innovation Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-69695572020-01-23 Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism Aggarwala, Karan R Gregg Med Hypothesis Discov Innov Ophthalmol Commentary Ocular accommodation is not just a mechanism for altering curvature of the crystalline lens of the eye, it also enables aqueous humor outflow through the trabecular meshwork, influencing intraocular pressure (IOP). Long term stress on the ciliary muscle from sustained near focusing may initiate myopic eye growth in children and primary open angle glaucoma in presbyopic adults. Multi-factorial studies of ocular accommodation that include measures of IOP, ciliary muscle morphology, anterior chamber depth and assessment of nutritional intake and metabolic markers may elucidate etiology and novel strategies for management of both myopia and chronic glaucoma. Anatomy of the ciliary fibers from anterior insertion in the fluid drainage pathway to their posterior consanguinity with the vascular choroid, alters ocular parameters such as micro-fluctuations of accommodation and pulsatile ocular blood flow that are driven by cardiac contractions conveyed by carotid arteries. Stretching of the choroid has consequences for thinning of the peripheral retina, sclera and lamina cribrosa with potential to induce retinal tears and optic nerve cupping. Early metabolic interventions may lead to prevention or reduced severity of myopia and glaucoma. Finally, it might improve quality of life of patients and decrease disability from visual impairment and blindness. Medical Hypothesis, Discovery & Innovation Ophthalmology 2020 2020-01-05 /pmc/articles/PMC6969557/ /pubmed/31976346 Text en © 2020, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License (http://creativecommons.org/licenses/by/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Commentary Aggarwala, Karan R Gregg Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism |
title | Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism |
title_full | Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism |
title_fullStr | Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism |
title_full_unstemmed | Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism |
title_short | Ocular Accommodation, Intraocular Pressure, Development of Myopia and Glaucoma: Role of Ciliary Muscle, Choroid and Metabolism |
title_sort | ocular accommodation, intraocular pressure, development of myopia and glaucoma: role of ciliary muscle, choroid and metabolism |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969557/ https://www.ncbi.nlm.nih.gov/pubmed/31976346 |
work_keys_str_mv | AT aggarwalakaranrgregg ocularaccommodationintraocularpressuredevelopmentofmyopiaandglaucomaroleofciliarymusclechoroidandmetabolism |