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Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits
The purpose of this study was to compare the effects of propranolol, timolol and bevacizumab with betamethasone to prevent corneal neovascularization (CNV) in rabbits. This study was performed on 28 male rabbits. CNV was induced by three 7-0 silk sutures 2 mm long and 1 mm distal to the limbus. Anim...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medical Hypothesis, Discovery & Innovation Ophthalmology
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969563/ https://www.ncbi.nlm.nih.gov/pubmed/31976343 |
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author | Kasiri, Ali Mirdehghan, Mohammad Sadegh Farrahi, Fereydoun Ostadian, Farshad Feghhi, Mostafa Ghomi, Mehdi Reza Mohammad Jafari, Aram Mahdian Rad, Atefeh Kasiri, Niusha |
author_facet | Kasiri, Ali Mirdehghan, Mohammad Sadegh Farrahi, Fereydoun Ostadian, Farshad Feghhi, Mostafa Ghomi, Mehdi Reza Mohammad Jafari, Aram Mahdian Rad, Atefeh Kasiri, Niusha |
author_sort | Kasiri, Ali |
collection | PubMed |
description | The purpose of this study was to compare the effects of propranolol, timolol and bevacizumab with betamethasone to prevent corneal neovascularization (CNV) in rabbits. This study was performed on 28 male rabbits. CNV was induced by three 7-0 silk sutures 2 mm long and 1 mm distal to the limbus. Animals were randomly divided into 4 groups of propranolol + betamethasone, timolol + betamethasone and bevacizumab + betamethasone and betamethasone alone. Eye drops were started from the first day of study. On 7(th), 14(th), 21(st), 28(th), 35(th) and 42(nd) days, vascular progression, time of neovascularization and vascular area were evaluated and compared with the control group (betamethasone alone). There was a significant reduction in the area of neovascularization in the timolol and bevacizumab groups compared to the control group (P-value = 0.05, P=0.047, respectively). Also, regarding vascular progression, there was a significant decrease in the timolol and bevacizumab groups (P-value = 0.014, P=0.002, respectively). Regarding delayed onset of neovascularization, there was a significant difference in the timolol and bevacizumab group in rabbits (P-value = 0.04, P=0.00, respectively). In conclusion, the use of timolol and bevacizumab drops besides betamethasone can delay neovascularization and decrease the length of corneal vascularization in rabbits. |
format | Online Article Text |
id | pubmed-6969563 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Medical Hypothesis, Discovery & Innovation Ophthalmology |
record_format | MEDLINE/PubMed |
spelling | pubmed-69695632020-01-23 Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits Kasiri, Ali Mirdehghan, Mohammad Sadegh Farrahi, Fereydoun Ostadian, Farshad Feghhi, Mostafa Ghomi, Mehdi Reza Mohammad Jafari, Aram Mahdian Rad, Atefeh Kasiri, Niusha Med Hypothesis Discov Innov Ophthalmol Original Article The purpose of this study was to compare the effects of propranolol, timolol and bevacizumab with betamethasone to prevent corneal neovascularization (CNV) in rabbits. This study was performed on 28 male rabbits. CNV was induced by three 7-0 silk sutures 2 mm long and 1 mm distal to the limbus. Animals were randomly divided into 4 groups of propranolol + betamethasone, timolol + betamethasone and bevacizumab + betamethasone and betamethasone alone. Eye drops were started from the first day of study. On 7(th), 14(th), 21(st), 28(th), 35(th) and 42(nd) days, vascular progression, time of neovascularization and vascular area were evaluated and compared with the control group (betamethasone alone). There was a significant reduction in the area of neovascularization in the timolol and bevacizumab groups compared to the control group (P-value = 0.05, P=0.047, respectively). Also, regarding vascular progression, there was a significant decrease in the timolol and bevacizumab groups (P-value = 0.014, P=0.002, respectively). Regarding delayed onset of neovascularization, there was a significant difference in the timolol and bevacizumab group in rabbits (P-value = 0.04, P=0.00, respectively). In conclusion, the use of timolol and bevacizumab drops besides betamethasone can delay neovascularization and decrease the length of corneal vascularization in rabbits. Medical Hypothesis, Discovery & Innovation Ophthalmology 2020 2020-01-01 /pmc/articles/PMC6969563/ /pubmed/31976343 Text en © 2020, Author(s). This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial 4.0 International License (http://creativecommons.org/licenses/by/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Original Article Kasiri, Ali Mirdehghan, Mohammad Sadegh Farrahi, Fereydoun Ostadian, Farshad Feghhi, Mostafa Ghomi, Mehdi Reza Mohammad Jafari, Aram Mahdian Rad, Atefeh Kasiri, Niusha Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits |
title | Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits |
title_full | Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits |
title_fullStr | Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits |
title_full_unstemmed | Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits |
title_short | Prevention of Corneal Neovascularization; a Preliminary Experimental Study in Rabbits |
title_sort | prevention of corneal neovascularization; a preliminary experimental study in rabbits |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969563/ https://www.ncbi.nlm.nih.gov/pubmed/31976343 |
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