Cargando…

Aloin Inhibits the Proliferation and Migration of Gastric Cancer Cells by Regulating NOX2–ROS-Mediated Pro-Survival Signal Pathways

BACKGROUND: Aloin has been reported to have many pharmacological effects including anti-inflammatory, anti-oxidant and anti-tumour activities. However, the precise molecular mechanisms underlying the anti-tumour properties of aloin are yet to be elucidated. METHODS: HGC-27 and BGC-823 gastric cancer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Ziqian, Tang, Tuo, Wang, Shengnan, Cai, Tianyu, Tao, Hong, Zhang, Qing, Qi, Shimei, Qi, Zhilin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969686/ https://www.ncbi.nlm.nih.gov/pubmed/32021099 http://dx.doi.org/10.2147/DDDT.S219247

Ejemplares similares

The molecular mechanisms of Aloin induce gastric cancer cells apoptosis by targeting High Mobility Group Box 1
por: Tao, Hong, et al.
Publicado: (2019)

Aloin suppresses lipopolysaccharide-induced inflammation by inhibiting JAK1-STAT1/3 activation and ROS production in RAW264.7 cells
por: Ma, Yunfei, et al.
Publicado: (2018)

High mobility group box 1 regulates gastric cancer cell proliferation and migration via RAGE-mTOR/ERK feedback loop
por: Tang, Tuo, et al.
Publicado: (2021)

Myricitrin Modulates NADPH Oxidase-Dependent ROS Production to Inhibit Endotoxin-Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47(phox) Pathways
por: Qi, Shimei, et al.
Publicado: (2017)

Aloin in Pregnancy
por: Sircir, P. B.
Publicado: (1932)

On the Therapeutics of Aloin
por: Craig, William
Publicado: (1877)

Salidroside inhibits the proliferation and migration of gastric cancer cells via suppression of Src-associated signaling pathway activation and heat shock protein 70 expression
por: Qi, Zhilin, et al.
Publicado: (2018)

Plasma, tissue and urinary levels of aloin in rats after the administration of pure aloin
por: Park, Mi-Young, et al.
Publicado: (2008)

On Aloin: The Cathartic Principle of the Aloes
Publicado: (1851)

Sandwich structure Aloin-PVP/Aloin-PVP-PLA/PLA as a wound dressing to accelerate wound healing
por: Li, Weiping, et al.
Publicado: (2022)

Notes on "Changed Aloin" and the Resin of Aloes
por: Craig, William
Publicado: (1875)

Notes on "Changed Aloin" and the Resin of Aloes
por: Craig, William
Publicado: (1875)

Evaluation of anti-infective potencies of formulated aloin A ointment and aloin A isolated from Aloe barbadensis Miller
por: Donkor, Addai-Mensah, et al.
Publicado: (2020)

Nuclear membrane-localised NOX4D generates pro-survival ROS in FLT3-ITD-expressing AML
por: Moloney, Jennifer N., et al.
Publicado: (2017)

Inhibition of ROS-mediated activation Src-MAPK/AKT signaling by orientin alleviates H(2)O(2)-induced apoptosis in PC12 cells
por: Qi, Shimei, et al.
Publicado: (2018)

CLEC5A regulates the proliferation and migration of colon cancer via the AKT/mTOR signaling pathway
por: Pan, Yang, et al.
Publicado: (2023)

Integrating Network Pharmacology and Experimental Verification to Explore the Pharmacological Mechanisms of Aloin Against Gastric Cancer
por: Gao, Jia, et al.
Publicado: (2022)

NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma
por: Su, Xiangsheng, et al.
Publicado: (2021)

NOX- and ROS-Driven Hypertension in Elastin Insufficiency
por: Gavazzi, Gaëtan, et al.
Publicado: (2021)

NOX-like ROS production by glutathione reductase
por: Diaz, Julia M., et al.
Publicado: (2022)

NOX Dependent ROS Generation and Cell Metabolism
por: Pecchillo Cimmino, Tiziana, et al.
Publicado: (2023)

High glucose promotes tumor cell proliferation and migration in lung adenocarcinoma via the RAGE-NOXs pathway
por: Liao, Yuan-Fan, et al.
Publicado: (2018)

Inhibition of the angiogenesis and growth of Aloin in human colorectal cancer in vitro and in vivo
por: Pan, Qin, et al.
Publicado: (2013)

NOX4-dependent ROS production by stromal mammary cells modulates epithelial MCF-7 cell migration
por: Tobar, N, et al.
Publicado: (2010)

Antitrypanosomal activity of aloin and its derivatives against Trypanosoma congolense field isolate
por: Tewabe, Yitagesu, et al.
Publicado: (2014)

Statins attenuate cholesterol-induced ROS via inhibiting NOX2/NOX4 and mitochondrial pathway in collecting ducts of the kidney
por: Wang, Ani, et al.
Publicado: (2022)

Impact of Nox5 Polymorphisms on Basal and Stimulus-Dependent ROS Generation
por: Wang, Yusi, et al.
Publicado: (2014)

NHE1 is upregulated in gastric cancer and regulates gastric cancer cell proliferation, migration and invasion
por: Xie, Rui, et al.
Publicado: (2019)

Aloin induced apoptosis by enhancing autophagic flux through the PI3K/AKT axis in osteosarcoma
por: He, Jiaming, et al.
Publicado: (2021)

Identification of CDPKs involved in TaNOX7 mediated ROS production in wheat
por: Hu, Chun-Hong, et al.
Publicado: (2023)

NOX4-derived ROS are neuroprotective by balancing intracellular calcium stores
por: Gola, Lukas, et al.
Publicado: (2023)

Angiotensin II Decreases Endothelial Nitric Oxide Synthase Phosphorylation via AT(1)R Nox/ROS/PP2A Pathway
por: Ding, Jing, et al.
Publicado: (2020)

lncRNA SNHG4 promotes cell proliferation, migration, invasion and the epithelial-mesenchymal transition process via sponging miR-204-5p in gastric cancer
por: Wang, Shimei, et al.
Publicado: (2021)

Nox4-dependent ROS modulation by amino endoperoxides to induce apoptosis in cancer cells
por: Zhu, P, et al.
Publicado: (2013)

ROS Stress Resets Circadian Clocks to Coordinate Pro-Survival Signals
por: Tamaru, Teruya, et al.
Publicado: (2013)

Aloin Suppresses Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Inhibiting the Activation of NF-κB
por: Luo, Xuan, et al.
Publicado: (2018)

Aloin Inhibits Müller Cells Swelling in a Rat Model of Thioacetamide-Induced Hepatic Retinopathy
por: Jung, Eunsoo, et al.
Publicado: (2018)

Regulation of Monocyte Adhesion and Migration by Nox4
por: Lee, Chi Fung, et al.
Publicado: (2013)

Exploration of the mechanism of aloin ameliorates of combined allergic rhinitis and asthma syndrome based on network pharmacology and experimental validation
por: Feng, Yan, et al.
Publicado: (2023)

SHMT1 inhibits the metastasis of HCC by repressing NOX1-mediated ROS production
por: Dou, Changwei, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_59crobc2hltbte0do3g39anop1