Cargando…

Synergy of Phospholipid—Drug Formulations Significantly Deactivates Profibrogenic Human Hepatic Stellate Cells

The pivotal role of hepatic stellate cells (HSCs) in orchestrating the bidirectional process of progression and regression of liver fibrosis makes them an ideal target for exploring new antifibrotic therapies. Essential phospholipids (EPLs), with their polyenylphosphatidylcholine (PPC) fraction, eit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Valentino, Gina, Zivko, Cristina, Weber, Florian, Brülisauer, Lorine, Luciani, Paola
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969915/ https://www.ncbi.nlm.nih.gov/pubmed/31842373 http://dx.doi.org/10.3390/pharmaceutics11120676

Ejemplares similares

Macrophage MerTK promotes profibrogenic cross-talk with hepatic stellate cells via soluble mediators
por: Pastore, Mirella, et al.
Publicado: (2022)

The Expression of HIV-1 Vpu in Monocytes Causes Increased Secretion of TGF-β that Activates Profibrogenic Genes in Hepatic Stellate Cells
por: Patel, Paresh, et al.
Publicado: (2014)

Activation of Mir-29a in Activated Hepatic Stellate Cells Modulates Its Profibrogenic Phenotype through Inhibition of Histone Deacetylases 4
por: Huang, Ying-Hsien, et al.
Publicado: (2015)

HIV and HCV Co-Culture Promotes Profibrogenic Gene Expression through an Epimorphin-Mediated ERK Signaling Pathway in Hepatic Stellate Cells
por: Shi, Lei, et al.
Publicado: (2016)

GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells
por: Arroyo, Noelia, et al.
Publicado: (2021)

Tamoxifen mechanically deactivates hepatic stellate cells via the G protein-coupled estrogen receptor
por: Cortes, Ernesto, et al.
Publicado: (2018)

Reciprocal induction of hepatitis C virus replication and stimulation of hepatic profibrogenic cytokine release and cellular viability by YKL-40
por: Cheng, Du, et al.
Publicado: (2021)

Molecular Determinants of Phospholipid Synergy in Blood Clotting
por: Tavoosi, Narjes, et al.
Publicado: (2011)

Arecae pericarpium water extract alleviates chronic pancreatitis by deactivating pancreatic stellate cells
por: Kweon, Bitna, et al.
Publicado: (2022)

Crosstalk between Epigenetic Modulations in Valproic Acid Deactivated Hepatic Stellate Cells: An Integrated Protein and miRNA Profiling Study
por: Lu, Peng, et al.
Publicado: (2019)

MicroRNA Function in the Profibrogenic Interplay upon Chronic Liver Disease
por: Huang, Jia, et al.
Publicado: (2014)

Hexa Histidine–Tagged Recombinant Human Cytoglobin Deactivates Hepatic Stellate Cells and Inhibits Liver Fibrosis by Scavenging Reactive Oxygen Species
por: Dat, Ninh Quoc, et al.
Publicado: (2021)

Oncostatin M, A Profibrogenic Mediator Overexpressed in Non-Alcoholic Fatty Liver Disease, Stimulates Migration of Hepatic Myofibroblasts
por: Foglia, Beatrice, et al.
Publicado: (2019)

Multimechanistic Antifibrotic Effect of Biochanin A in Rats: Implications of Proinflammatory and Profibrogenic Mediators
por: Breikaa, Randa M., et al.
Publicado: (2013)

Mucosal-associated invariant T cells are a profibrogenic immune cell population in the liver
por: Hegde, Pushpa, et al.
Publicado: (2018)

Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo
por: Khodayari, Nazli, et al.
Publicado: (2020)

Profibrogenic macrophage-targeted delivery of mitochondrial protector via exosome formula for alleviating pulmonary fibrosis
por: Zhang, Wei, et al.
Publicado: (2023)

Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells
por: Qin, Dong, et al.
Publicado: (2020)

A Novel Way of Preventing Postoperative Pancreatic Fistula by Directly Injecting Profibrogenic Materials into the Pancreatic Parenchyma
por: Lee, Sang Chul, et al.
Publicado: (2020)

ROCK2 inhibition attenuates profibrogenic immune cell function to reverse thioacetamide-induced liver fibrosis
por: Nalkurthi, Christina, et al.
Publicado: (2021)

Tracking matricellular protein SPARC in extracellular vesicles as a non-destructive method to evaluate lipid-based antifibrotic treatments
por: Zivko, Cristina, et al.
Publicado: (2022)

Immunometabolism Modulation by Extracts from Pistachio Stalks Formulated in Phospholipid Vesicles
por: Pani, Simone, et al.
Publicado: (2023)

Hepatic Stellate Cells and Hepatocarcinogenesis
por: Barry, Anna E., et al.
Publicado: (2020)

Catalyst deactivation /
Publicado: (1999)

MMP‐13 deletion decreases profibrogenic molecules and attenuates N‐nitrosodimethylamine‐induced liver injury and fibrosis in mice
por: George, Joseph, et al.
Publicado: (2017)

CCR5+ T-Cells Homed to the Liver Exhibit Inflammatory and Profibrogenic Signatures in Chronic HIV/HCV-Coinfected Patients
por: Shrivastava, Shikha, et al.
Publicado: (2021)

Permissive effect of GSK3β on profibrogenic plasticity of renal tubular cells in progressive chronic kidney disease
por: Chen, Bohan, et al.
Publicado: (2021)

ANGPTL4 suppresses the profibrogenic functions of atrial fibroblasts induced by angiotensin II by up-regulating PPARγ
por: Zhu, Xi, et al.
Publicado: (2023)

Formulated Phospholipids as Non-Canonical TLR4 Agonists
por: Liang, Hong, et al.
Publicado: (2022)

Immortal hepatic stellate cell lines: useful tools to study hepatic stellate cell biology and function?
por: Herrmann, Jens, et al.
Publicado: (2007)

Accelerated CCl(4)-Induced Liver Fibrosis in Hjv-/- Mice, Associated with an Oxidative Burst and Precocious Profibrogenic Gene Expression
por: Sebastiani, Giada, et al.
Publicado: (2011)

Profibrogenic effect of high-mobility group box protein-1 in human dermal fibroblasts and its excess in keloid tissues
por: Lee, Won Jai, et al.
Publicado: (2018)

Liver Glycogen Phosphorylase Deficiency Leads to Profibrogenic Phenotype in a Murine Model of Glycogen Storage Disease Type VI
por: Wilson, Lane H., et al.
Publicado: (2019)

Adherent invasive Escherichia coli (AIEC) strain LF82, but not Candida albicans, plays a profibrogenic role in the intestine
por: Chokr, Dina, et al.
Publicado: (2021)

PPAR Gamma and Hepatic Stellate Cells
por: Hazra, Saswati, et al.
Publicado: (2004)

Development of polyherbal antidiabetic formulation encapsulated in the phospholipids vesicle system
por: Gauttam, Vinod Kumar, et al.
Publicado: (2013)

Pharmacokinetic and Pharmacodynamic Profile of a Novel Phospholipid Aspirin Formulation
por: Angiolillo, Dominick J., et al.
Publicado: (2022)

Hepatic stellate cells: central modulators of hepatic carcinogenesis
por: Thompson, Alexandra I, et al.
Publicado: (2015)

Interpreting Deactivations in Neuroimaging
por: Hayes, Dave J., et al.
Publicado: (2012)

Clinical significance and gene expression study of human hepatic stellate cells in HBV related-hepatocellular carcinoma
por: Liao, Rui, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qcvptrlb06c603oe77g95odn4e