Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection

Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulen...

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Autores principales: Nie, Dan, Hu, Yue, Chen, Zhou, Li, Mingkai, Hou, Zheng, Luo, Xiaoxing, Mao, Xinggang, Xue, Xiaoyan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969976/
https://www.ncbi.nlm.nih.gov/pubmed/31954394
http://dx.doi.org/10.1186/s12929-020-0617-7
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author Nie, Dan
Hu, Yue
Chen, Zhou
Li, Mingkai
Hou, Zheng
Luo, Xiaoxing
Mao, Xinggang
Xue, Xiaoyan
author_facet Nie, Dan
Hu, Yue
Chen, Zhou
Li, Mingkai
Hou, Zheng
Luo, Xiaoxing
Mao, Xinggang
Xue, Xiaoyan
author_sort Nie, Dan
collection PubMed
description Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli (E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii. In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target.
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spelling pubmed-69699762020-01-27 Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection Nie, Dan Hu, Yue Chen, Zhou Li, Mingkai Hou, Zheng Luo, Xiaoxing Mao, Xinggang Xue, Xiaoyan J Biomed Sci Review Acinetobacter baumannii (A. baumannii) is an important opportunistic pathogen causing serious nosocomial infections, which is considered as the most threatening Gram-negative bacteria (GNB). Outer membrane protein A (OmpA), a major component of outer membrane proteins (OMPs) in GNB, is a key virulence factor which mediates bacterial biofilm formation, eukaryotic cell infection, antibiotic resistance and immunomodulation. The characteristics of OmpA in Escherichia coli (E. coli) have been extensively studied since 1974, but only in recent years researchers started to clarify the functions of OmpA in A. baumannii. In this review, we summarized the structure and functions of OmpA in A. baumannii (AbOmpA), collected novel therapeutic strategies against it for treating A. baumannii infection, and emphasized the feasibility of using AbOmpA as a potential therapeutic target. BioMed Central 2020-01-18 /pmc/articles/PMC6969976/ /pubmed/31954394 http://dx.doi.org/10.1186/s12929-020-0617-7 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Nie, Dan
Hu, Yue
Chen, Zhou
Li, Mingkai
Hou, Zheng
Luo, Xiaoxing
Mao, Xinggang
Xue, Xiaoyan
Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
title Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
title_full Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
title_fullStr Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
title_full_unstemmed Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
title_short Outer membrane protein A (OmpA) as a potential therapeutic target for Acinetobacter baumannii infection
title_sort outer membrane protein a (ompa) as a potential therapeutic target for acinetobacter baumannii infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6969976/
https://www.ncbi.nlm.nih.gov/pubmed/31954394
http://dx.doi.org/10.1186/s12929-020-0617-7
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