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ERRα activates SHMT2 transcription to enhance the resistance of breast cancer to lapatinib via modulating the mitochondrial metabolic adaption

Lapatinib, a tyrosine kinase inhibitor, can initially benefit the patients with breast tumors but fails in later treatment due to the inevitable development of drug resistance. Estrogen-related receptor α (ERRα) modulates the metabolic adaptations in lapatinib-resistant cancer cells; however, the un...

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Detalles Bibliográficos
Autores principales:	Li, Xin, Zhang, Kejing, Hu, Yu, Luo, Na
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Cancer
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6970080/ https://www.ncbi.nlm.nih.gov/pubmed/31894856 http://dx.doi.org/10.1042/BSR20192465

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